Who all take Sulforaphane- Safe to take in metastatic disease or risky ?

[Tinkudi]

Who all here with metastatic disease are taking Sulforaphane and what dose.

Do you think it helped ?

There is mixed advise whether to take it or avoid it when one has metastatic disease so it is confusing.

“ NRF2 Activation**: Sulforaphane activates the NRF2 pathway, which can have dual roles in cancer. While NRF2 activation can enhance cellular defense mechanisms and provide anticancer effects, it may also promote cancer cell survival in certain contexts. This duality necessitates careful consideration and monitoring when using sulforaphane, especially in the presence of metastatic cancer”

[muttonman]

eat cruciferous vegetables instead.....green juice every day, kale, ginger, lemon, green apples, celery

[85745 in reply to muttonman]

Do geen apples have any benefits ?

[85745]

I eat cruciferous vegetables along with Broc and radish sprouts ( sulforaphane ). I was taking it in several supplement forms including DIM. Maybe I am better off eating junk food. Thanks for the info.

[dhccpa in reply to 85745]

I grow sprouts as well. How big are the sprouts before you consume them?

[85745 in reply to dhccpa]

Harvest them when they first green up in the mason jar.

[dhccpa in reply to 85745]

Thanks. I've been waiting just a little too long.

[lcfcpolo]

I take Prostaphane (BROQ) capsules, either one or 2 daily. So far, along with everything else, including standard of care Lupron injections and Enzalutamide, it may have helped. I just do not what works. I've been taking them for approximately 3 years. There are no long term trials to prove or disprove it's effect.

[Tinkudi in reply to lcfcpolo]

Hey.

Well so it does not seem to have harmed you for sure as you have good numbers right ?

[lcfcpolo in reply to Tinkudi]

Yes good numbers but I have another blood test on Thursday so no idea on if the numbers will remain so but so far so good, just over 4 years since diagnosis.

[Tinkudi in reply to lcfcpolo]

Best of luck to you 😊. You do the care clinic protocol too right

[lcfcpolo in reply to Tinkudi]

Yes

[lokibear0803]

I've been doing BroccoMax for a few years by now. I have no idea whether it's helpful or not, but I don't think it's harmful for me -- here's what I've found about NRF2:

ncbi.nlm.nih.gov/pmc/articl...

Nrf2 has a dual role in cancer development and therapy. Based on a body of studies, it seems that transient activation of Nrf2 in normal cells (where the Nrf2-Keap1 axis is intact) is protective; however, constitutive activation of Nrf2 (mutation of Keap1) promotes the survival and progression of malignant cells.

Since I have no KEAP1 mutations, I don't worry about the NRF2 issue.

[Tinkudi in reply to lokibear0803]

So as per your understanding only if one has that mutation then the sulfurophane may be risky ?

Your psa numbers have been good ?

[lokibear0803 in reply to Tinkudi]

Yeah, that's the best I can tell you. Read that article for all the details about the NRF2-Keap1 relationship. My PSA numbers have been good - but I'm not ready to give the SFN credit for that. I'm taking relugolix + I have the SPOP mutation, which gives me excellent responder status with anti-androgens.

[dhccpa]

I've taken it here and there. I also eat a fair amount of cruciferous vegetables. Hard to say if it's done anything.

I also grow sprouts. Radish and broccoli so far the past two years.