research summary?: Some asked about my... - Advanced Prostate...

Advanced Prostate Cancer

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research summary?

Maxone73 profile image
18 Replies

Some asked about my own feelings about the most exciting fields in oncology which could bring results. I should take a long moment to sit and summarize all the papers and also to check the moves of bit pharma companies...but right now I cannot (but I might use some AI to do the job soon!). But for not I will go with gut feelings and some observations.

Of course, what I am going to say is not complete and it's my opinion only, but it's an interesting topic to explore for the next future.

So, I think we are moving in a few different directions:

- ADCs (antibody drugs conjugates): most research from different sources is converging to positive or even very positive results....and big investments from huge companies like AZ (which is not Arizona!) are pointing there. Precision delivery of payloads and some help for standard chemo;

- radio theranostics: if CU-67 sar-bispsma keeps going on as it is going now, with incredibly good results and very low toxicity, I would not be surprised to see Pluvicto disappear in few years. Also in this case there are huge investments behind the scene;

- CRISPR: I am a big fan! In this case a lot is related to how successful the two therapies about sickle cells and thalassemia will be. To my knowledge till today (almost 6 months) a single treatment produced 100% remission and there are few lucky guys who don't need transfusions anymore. Expensive? Yes at the moment, even if not that expensive if you compare it to the cost of a cancer patient being alive for like 10 years. Cancer focused? Kind of, but not yet. It will really become hot and people will stop being scared about it (oh don't touch my genes please!!) if these first non oncological therapies will succeed. But it's a super hot subject when it comes to create platforms that can predict the behaviour of proteins and so on. for this purpose it's being already widely used in oncology;

- delivery techniques (apart from ADC): there is a LOT being done in this field, also because it's promising from a speed point of view. Such systems basically deliver existing or new chemotherapies in a highly selective way, giving them an extremely low toxicity, making them also more repeatable and usable also with fragile patients. This is the field where in the past 2 months I have seen the most new research. It's probably the cheapest option (apart for ADCs) and as I said, less stuff to be tested if it delivers known chemotherapies.

Immunotherapy is doing great things but not yet hitting PCa as we would like. Repurposing is making good steps forward but as adjuvant (which is important anyway).

Oh whichever comes first is welcome of course!! 😜😜😜

Have a great weekend!

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18 Replies
KocoPr profile image
KocoPr

All great things Max!!! I love the positive approach and as you, I am very excited for our future. I think this wack-a-Mole approach with inhibiting specific pathways is just about over.

Researcher50 profile image
Researcher50

I follow your postings all the time, but get a little lost in the technical jargon! This summary was great. Ty for taking the time to do this.

God_Loves_Me profile image
God_Loves_Me

Thank you Max..

Wagon-Wheel profile image
Wagon-Wheel

I will tag along. I appreciate your dedication to posting new research. Progress gives me hope for a longer future.

zeitgeistxx profile image
zeitgeistxx

Thank-you very much for your hard work and positive attitude. You are appreciated. 🙂

God_Loves_Me profile image
God_Loves_Me

CRISPR

A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors

clinicaltrials.gov/study/NC...

God_Loves_Me profile image
God_Loves_Me

Max - Can you share clinical trials for following please ?

- delivery techniques (apart from ADC): there is a LOT being done in this field, also because it's promising from a speed point of view. Such systems basically deliver existing or new chemotherapies in a highly selective way, giving them an extremely low toxicity, making them also more repeatable and usable also with fragile patients. This is the field where in the past 2 months I have seen the most new research. It's probably the cheapest option (apart for ADCs) and as I said, less stuff to be tested if it delivers known chemotherapies.

Maxone73 profile image
Maxone73 in reply toGod_Loves_Me

Ok! Give me a few days, maybe hours

Maxone73 profile image
Maxone73 in reply toGod_Loves_Me

I don’t even remember if there are clinical trials, preclinical for sure

God_Loves_Me profile image
God_Loves_Me

64Cu-SAR-bisPSMA and 67Cu-SAR-bisPSMA for Identification and Treatment of PSMA-expressing Metastatic Castrate Resistant Prostate Cancer (SECuRE) (SECuRE)

clinicaltrials.gov/study/NC...

God_Loves_Me profile image
God_Loves_Me

ADC Trials Antibody-Drug Conjugates

FOR46 in Combination With Enzalutamide in Patients With Metastatic Castration Resistant Prostate Cancer

clinicaltrials.gov/study/NC...

ARX517 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ARX517)

clinicaltrials.gov/study/NC...

Phase I/​II Trial of Pembrolizumab and Androgen-receptor Pathway Inhibitor With or Without 225Ac-J591 for Progressive Metastatic Castration Resistant Prostate Cancer

clinicaltrials.gov/study/NC...

Study of XB002 in Subjects With Solid Tumors (JEWEL-101)

clinicaltrials.gov/study/NC...

Study of Dato-Dxd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

clinicaltrials.gov/study/NC...

A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors

clinicaltrials.gov/study/NC...

Retireddoc profile image
Retireddoc

This summary is much appreciated. I am a 71 year old retired physician who was diagnosed almost 3 years ago with G9. Have had RP, triplet therapy and pelvic radiation with know mets at T8 and a single pelvis node. T8 radiated with SBRT with good result. Like many others, I am hoping for breakthrough treatments should/as my prostate cancer progresses. I am currently off all medication with an undetectable PSA.

Any links to the research or trials would be helpful.

Maxone73 profile image
Maxone73 in reply toRetireddoc

Hi! You can check my old posts if you want, 95% of them are about clinical trials or preclinical research!

Retireddoc profile image
Retireddoc in reply toMaxone73

Thanks

j-o-h-n profile image
j-o-h-n

Thanks, but you forgot to include the most exciting field, which is HUMOR.

Thanks, I'm enjoying my weekend...... and I hope you're enjoying yours.

Good Luck, Good Health and Good Humor.

j-o-h-n

Z06505hp profile image
Z06505hp

Very interesting. I just received my second treatment of Pluvicto and is working very well. I am very intrigued with CU-67. I just read about it not to long ago. Seems to be very effective.

Peppertree602 profile image
Peppertree602

I certainly appreciate all the time and effort you to put in! I read all of your post with enthusiasm.

Maxone73 profile image
Maxone73 in reply toPeppertree602

Thanks!! 😀

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