My partner has advanced PC with tumours in ribs, spine and iliac. He has been stable on Zoladex for 8 years but this may now be changing. We insisted on a BRCA test which has come back negative but from what I understand Olaparib is only being made available to patients in the UK for those who test positive. I am wondering if this is purely down to cost (Nice will cap certain drugs for us) or whether I will have to fight for it as it is better than say Docetaxel. He has not had chemo yet - only radiotherapy at the outset. Awaiting bone scan and ct results but I have a feeling that things are changing with fatigue levels falling off a cliff and pain in L2 region of spine where there is a tumour. He has had no bone pain at all up until now. There have been many new treatments coming through since I last was on this site - probably about 5 years ago as we just needed to get on with life whilst we can. But now here we are ....
In the UK Olaparib only seems to be a... - Advanced Prostate...
In the UK Olaparib only seems to be available for those testing positive for BRCA. Is this a cost issue that it is not widely available?
Not sure how effective it is for those of us that are not BRCA2+
Good reading, I need help. I might be wrong, I spent 30 min and believe here is the clinical trials for patient who has not reported BRCA2+.
there were clinical trials for the patients who has not detected BRCA2+
It is ineffective in men without the BRCA mutation:
prostatecancer.news/2019/10...
And it is very toxic -- it has some awful side effects.
Docetaxel is much better.
This is my husbands next step we are told down the road when he becomes castrate resistant. Scares me to death to hear this as he just finished chemo 3 weeks ago and that was not all that fun. So he is expected to have awful side effects?
Olaparib should never be used in men who are not BRCA+
My husband is BRCA2 positive . I was just commenting because we are told down the road this will be what they put him on , when nubeqa starts to fail . Scary hearing this is so bad for side effects
Hello Beej59 and Partner,
How old is your Partner? As for us Yanks what is "Nice will cap certain drugs for us".
Keep on posting...
Thanks, I hate abbrv......
Good Luck, Good Health and Good Humor.
j-o-h-n
T.H.A.N.K.S. similar to THANK YOU...in the U.K.
Good Luck, Good Health and Good Humor.
j-o-h-n
Bone mets and no Recommendes treatment 
help - prostate cancer with bone metastasis in bones - patient 70 years old - PERU
Radiotherapy fatigue
Is my husbands treatment working?
Radium 223 and external beam radiation
