PSA rise after triplet therapy

[wiirz]

Hi everyone, my dad was diagnosed with stage 4 metastatic prostate cancer in 2023. He commenced on Triplett therapy - Zoladex, Darolutamide & Docetaxel chemo. His PSA has started to rise measuring 0.9 in January, 1.6 in February & 2.1 in March. We saw the MO yesterday and she recommended we see her again in 1 month. Please advise. Thank you

[Tall_Allen]

They will probably order a PET/CT to see if there is progression of metastases.

[wiirz in reply to Tall_Allen]

will there be any change in medications ?

[Tall_Allen in reply to wiirz]

It depends on what the imaging shows.

[God_Loves_Me in reply to Tall_Allen]

Agree with Tall_Allen, I can suggest schedule radiations oncologist appointment in advance, once you have results. may be RO can radiate it.

[GP24]

I recommend a genetic test to see if that indicates which drugs to use. The progression is too rapid. Next medication would be a chemo with Cabazitaxel.

[RoseDoc]

He needs a PSMA scan to locate the source.

[raoulmaher]

Hi I am in a similar position to your Dad , I am currently 63 yrs old ( UK) and am on soladex and enzolutimide and am fortunuately still 0.03 PSA after an initial 51 - I hope this helps- genetics are good apparently to see how agressive your varient is and also wether it has non expressive elements and yes PET scan should help I am led to believe - Does this work with non expressive does anybody know ? - Tall allen ? - What was your Dads starting PSA and how long ago was he diagnosed - kindest Raoul