Starting Chemo again, Cabazitaxel Has anybody experienced any side effects that have been unusually bad?

[redbank]

After having been NED for the past six years I now have to go back on Chemo treatments. The first round of Chemo was with Taxotere and now My Cancer has become castrate resistant. PSA is now no longer a good indicator for disease progression. I'm not looking forward to doing this but it's what has to be done. I'm wondering if any of you guys have experienced any adverse side effects other than the usual nausea, hair loss etc.?

[ron_bucher]

I haven't yet, but probably will this year. One of my oncologists thinks cabazitaxel is generally more effective than taxotere, and he said the side effects are usually same or less.

[Seasid in reply to ron_bucher]

I made to believe that Docetaxel is less damaging to the bone marrow. Otherwise the main positive reason for me would be to get Jevtana is that it is crossing the blood brain barrier and hopefully prevent brain metastasis? Otherwise I stopped Docetaxel after 6th cycles because I started to experience grade one peripheral neuropathy in my fingers and feet.

[Yadifan]

My husband is currently on cabazitaxel. He just had treatment #9 two days ago. He has tolerated it a little better than docetaxel. There is some fatigue and occasional nausea. Mostly has trouble trying to find a food that sounds good to him. Best of luck to you. Please ask your MO about anti-nausea meds. You may not need them but they are nice to have in case.

[j-o-h-n in reply to Yadifan]

"food that sounds good to him (and me)"

Chocolate chip ice cream (two scoops)....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 01/19/2024 11:31 PM EST

[Yadifan in reply to j-o-h-n]

Ha!! This is so true! He does like his ice cream!!!

[Islandboy2021]

I am having 10 rounds of Docetaxel for the second time. I am having digestive issues. Inflammation in my face, my eyes are bothering me and I look very different than I did before starting. I have been able to work the last two weeks between treatments. I take it easy the first week.

[dockam]

Hi, had a two rounds of Taxotere in 2015 (15) and 2021(6). Did Cabazitaxels (18) from 2021/2022. No hair loss, or any major SEs. As I did with the Taxotere sessions, I fasted 2 days prior to each. That may have lessened the severity of the SEs.

Cabazitaxels didn't work tho, PSA was rising 50% each month from 11/22.

google.com/search?q=fasting...

28 IMRTS last Spring so far has PSA in single digits 💙.

Fight on

QoL on

[Seasid in reply to dockam]

I am in a similar situation like you. I also had radiation therapy SBRT of my prostate but the cancer is back in my prostate therefore I don't believe that an aggressive CRPC like I have in my prostate could be kiled easily with SBRT. Maybe I made a mistake that I didn't choose IMRT like you, but I was hoping that to show up 5 times for radiation therapy SBRT will be enough. I think prostate SBRT is still not proven as an effective treatment of an aggressive CRPC in the prostate. How did you decide to get IMRT? I believe that initially you wanted SBRT but you ended up getting 28 IMRTs and I believe that is a better choice.

[dockam in reply to Seasid]

Hi, in my query to RO he wrote this

" IMRT is the way to go in my opinion. SBRT for your situation is not appropriate (its for low risk gland confined disease, my plan for you will include the lymph nodes in the pelvis as well as the extensive local tumor that is beyond the gland). Brachytherapy would be similarly inappropriate to SBRT."

My Best to you Brother

Fight on

QoL on

[Seasid in reply to dockam]

I agree with your RO.

[Islandboy2021 in reply to dockam]

Hi dockam, where was your IMRT targeted. I had 20 targeted radiation treatment to the prostate over 20 days back in 2018. Recently I had one treatment to a painful spot on my ribs. I don't understand the difference between IMRT and SBRT.

Thanks

[dockam in reply to Islandboy2021]

Hi, PSMA from Fall 22 showed L of prostate filled with PCa, and it was heading South to perineum So targets were prostate and the lymph nodes in the pelvis as well as the extensive local tumor that is beyond the gland

youtu.be/kIWAv9oRD0c?si=0_y...(Not working as expected?)

Fight on

QoL on