Detection of Small Cell Prostate Cancer

[dac500]

I understand Small Cell Prostate Cancer (SCPC) may produce less PSA. How do you detect SCPC? Is it detectable by PSMA PET/CT scan?

[antisocialsocialwrkr]

This is a great question. Unfortunately, the current practice is only patients who have specific clinical features (like metastasis to visceral organs such as the liver) are usually recommended for a biopsy of the tumor. From there, they diagnose.

[antisocialsocialwrkr in reply to antisocialsocialwrkr]

My dad has it. He seemed perfectly fine as he received his hormone therapy and his PSA was always undetectable. And then one day, out of nowhere, he had some pain in his skull, a CT scan was done and they found spots on his liver and did a biopsy.

[Tall_Allen]

It is only detectable via biopsy histology and IHC. NEPC is not detectable via imaging (GI neuroendocrine can be detected with68GaDOTATATE).

[antisocialsocialwrkr in reply to Tall_Allen]

TA, will you give me your thoughts on the CHAMP trial? My dad is being evaluated for it. Why can’t I find phase 1 results anywhere?

[Tall_Allen in reply to antisocialsocialwrkr]

Why do you think a Phase I trial was done? The doses of cabazitaxel, carboplatin, nivolumab, and ipilimumab appear to be standard dosing of already-approved medicines, so there would be no need for a dose-finding trial.

I like it for men with metastases that express a lot of PD-L1. Otherwise, I'm more hopeful about the DLL-3 trials, if he expresses that.

prostatecancer.news/2016/12...

[j-o-h-n in reply to antisocialsocialwrkr]

you asked, you got...........We know how to be social...........

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 12/02/2023 1:25 PM EST