LU-177 Pluvicto -Husband will start treatment in one week. Looking for suggestions to help with side effects of lacrimal, salivary and liver

[Lavabeach]

Please let me know what you have done pre, during and after treatment to try to protect the body

against beta radiation from LU-177 Pluvicto. There was a clinical study on PubMed where

they iced patient's neck, provided eye drops, polyglutamate folate tablets and 10% mannitol solution for the above side effects.

Any suggestions please.

Has anyone used amifostine- (Ethyol) IV before injection starts?

[j-o-h-n]

There are tons of posts regarding Pluvicto here on H.U., Just view history...

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 10/29/2023 11:00 PM DST

[leebeth]

My husband sucked on sour candy during and after treatment. My brother did nothing.

Neither had side effects of any kind, until my brother developed bone marrow suppression.

My husband actually improved after each treatment, and felt better within about 4 hours after treatment.

[Lavabeach in reply to leebeth]

Hi leebeth,

Thank you so much for responding and sharing the experiences of your brother and husband.

[TTJJ1]

I had 5 infusions of Pluvicto; the last one was 7 weeks ago. The only lasting SE is dry mouth and tongue, some taste issues. The taste issue is almost back to normal, but the dry mouth has persisted. I did ice chips before, during, and after infusion. Several visits with oral medicine at Dana Farber with various treatments which none have helped resolve the issue. My MO said this may resolve over time but could be permanent. I was not in a clinical trial study but a PA that was overseeing the trial indicated that icing during treatment did not seem to help those in the trial. As you see from HU, response differs for each individual.

On the bright side I had substantial reduction in PSA and PSMA-PET showed significant response.

Do not hesitate to reach out if you have any questions.

Best of success to you – stay strong.

[Lavabeach in reply to TTJJ1]

Hi TTJJ1,

I appreciate that you have taken the time to respond. I understand that everyone is an individual and has different side effects to these treatments. This forum is a valuable resource e for all of us and I am grateful to have found it.

[j-o-h-n in reply to TTJJ1]

Do a search of H.U. history from May of this year (2023) for the following very informative post for Dry Mouth. I can't post it her cause it's over 7000 characters. I'll send it to your Private Message site.

Dry Mouth & the Advanced PC Patient (for those on Pluvicto or meds or ICI, where a side effect is dry mouth) - A Guide

rsgdmd profile image

rsgdmd•

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/30/2023 1:37 PM DST

[Lavabeach in reply to j-o-h-n]

Thank you for the information.

[TeleGuy]

The docs where I was treated in Munich said that nothing has conclusively been shown to help. One nurse there gave me lemon slices to suck on, but hard to tell if that made a difference! I have mild symptoms years after, need to have a glass of water nearby when I eat something dry like crackers.

[Lavabeach in reply to TeleGuy]

Hi Teleguy,

Thank you for your response. I appreciate your input.

[j-o-h-n]

See your Private Message P.M. site (box) for old post.

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/30/2023 1:43 PM DST

[LongTimeRunning]

I haven't done anything specific other than push, push, push fluids. Haven't noticed any reduction in saliva production. The first couple of mornings after treatment I get a slight nausea which goes away with food. I lift weights and bike (indoor) with extra layers to sweat extra (big pile of clothes for subsequent 3x washings) during the first couple of days. The first couple of nights suck because I'm going to the bathroom ~ every hr because of pushing fluids which I believe a necessary evil, until the 3rd night I ease off. Note that it is important to maintain electrolytes during this time, so salty and potassium-rich food are a good idea.

Getting my 5/6 infusion Thursday. A number of my blood parameters tend to drop after treatment (WBC, RBC, platelets), but tend to rebound subsequently. My liver enzymes (ALT/AST) tended higher earlier in the treatment plan but now are within or slightly over the reference ranges.

[Lavabeach in reply to LongTimeRunning]

Hi longtimerunning,

Thank you for sharing your experience. I am glad you are doing well on the treatment. Wishing the best outcome for you.

[meowlicious99]

i have this saved. Not sure if its relevant

healthunlocked.com/advanced...