Association of Treatment With 5α-Reductase Inhibitors With Time to Diagnosis and Mortality in Prostate Cancer

[snoraste]

Not entirely in line with other pieces on the subject:

“The prediagnostic use of 5α-reductase inhibitors appears to be associated with delayed prostate cancer diagnosis and an increased mortality risk.”

practiceupdate.com/C/83373/...

[snoraste]

I think you need to register. It’s free.

[tango65]

Try any of these 2 links:

sci-hub.tw/https://jamanetw...

jamanetwork.com/journals/ja...

[Tall_Allen]

It's easy to misunderstand the point of their "community practice" study.. 5aris actually increase the diagnostic accuracy of the PSA test if used properly. 5aris reduce the PSA from BPH but not the PSA from prostate cancer. So for men taking it:

1) If it doesn't reduce PSA, the PSA is probably due to PCa or prostatitis.

2) If it reduces PSA, but then PSA increase while taking it, it is a good indicator of cancer progression.

[PhilipSZacarias in reply to Tall_Allen]

Very interesting. I would like to read further on this topic. Can you refer me to one reference to get started. Thanks. Phil

[snoraste in reply to PhilipSZacarias]

If you do a search on this site for “5 alpha reductase “ you will see a few results. In fact the first result is a similar study that Patrick posted recently.

[PhilipSZacarias in reply to snoraste]

Thank you snoraste - I should have thought of that.

[Tall_Allen in reply to PhilipSZacarias]

Here ya go:

academic.oup.com/jnci/artic...

auajournals.org/doi/10.1016...

onlinelibrary.wiley.com/doi...

ncbi.nlm.nih.gov/pmc/articl...

[PhilipSZacarias in reply to Tall_Allen]

Many thanks, Allen