My husband was diagnosed in Jul 2021 PSA 41 at the time, multiple mets in bones. n1b and m1b Gleason 4+3=7. I've been reading and trying to get as much info as possible from this website. Last Oct PSA shot up to 19. Xtandi started and he also gets the 3monthly Prostap injections. PSA went back down to 2.55 in May and has had a steady increase since then. 4.24 in Aug and 5.96 in Oct. Oncologist appointment on the 3rd of Nov. We're not sure what the next plan of action might be? His hip was quite compromised with the mets at diagnosis. Had been fairly pain free after chemo but he has started developing more pain in his hip. Any suggestions on perhaps next best treatment options would be appreciated. His mother had ovarian cancer, would it be worthwhile to get a BRCA test for optional therapies? Request a PSMA pet scan? Further CT or bone scans? Change from Xtandi? Any and all suggestions appreciated. Thank you.
1st Time posting. Need suggestions pl... - Advanced Prostate...
1st Time posting. Need suggestions please.
Radiating the mets will reduce the pain.
Genetic panel is a must and it’s becoming standard practice. Have you looked into clinical trials?
Thank you. I'll see what I can find here in the UK.
Watching right now a live webcast for arx517 from Esmo 2023, a new molecule for mCRPC, check it out. Later I will check for the trial number. They are fast tracking to phase 3.
Can't thank enough. I'll see what I can find out.
Hi! Another potentially good one!
Thanks to skiingfiend !!
He should get both a germline (blood or saliva) and a somatic (tumor tissue) genomic test. If he is positive for a BRCA mutation, a PARP inhibitor may be beneficial. Pluvicto may be a good idea if he is PSMA-avid but not discordant on an FDG PET scan. If not available in the UK, he can get it in Germany or India.
Thank you so much Tall Allen.
Is the information from each of the tests different. For example, my husband had both tests. Germline did not show BRCA, but the genomic test did show BRCA2. Is BRCA2 worse if it’s Germline positive, or does it even matter.
Genomic "breakdown" occurs in metastases. So, in about half the cases, BRCA2 will not occur in germline, but will occur in somatic. PARP inhibitors are equally effective.
Are the Parp inhibitors started when/if he becomes mcrpc? Or should they start as soon as we got the test results back for BRCA ? He currently just takes Lupron, Zytiga and prednisone, and he’s getting SBRT once mapping is done. His PSA is .09 and testosterone undetected.
They are toxic. I don't know if there is any benefit in beginning to use them before there are significant numbers of DNA-mutated clones that would have been destroyed if BRCA were patent. There are a couple of clinical trials using them earlier, so we will soon know the answer:
You are in the right place and I commend you on your support and follow up for him. These posters here are amazing and there is always new help and answers. Give yourself time to learn the maze and the terms. Lots of love here. Hugs to you, Kate
My self I prefer natural remedies for all my illnesses, I have had lots of issues with my prostate being large & shutting of my urine flow since 2005 with pain in the groin area making it hard to sit down, two weeks ago I bought FenBen which was originally made to wipe out Animals parasites it has recently been used by men as it has a anti- cancer effect on the body, I found out that there is a one cell parasite that thrives in the prostate it creates cancer causing chemicals from its feces which creates cysts that become inflamed & increases the size of the prostate however by taking one 222 mg of FenBen for 10 days the pain in my prostate & groin diminished 90% I have stopped taking it & will start it again in 4 days time as a prolonged course is required to kill the larvae of the Parasites, I am not a specialist I am not a doctor I’m just a ordinary man finding solutions to my prostate problems so if you find my information very interesting then visit
> Fenbendazole.org for humans <& research this information before buying FenBen I bought mine from the the USA as in the UK they are capsules or powder only but Amazon sell this product. Good Luck
Greeting Akita123,
Sometimes you have to take something with a grain of salt...... sometimes you need a whole shaker full. I suggest you view an old post labeled "Miracle Enzymes" from 4 years ago and make your own decision on the amount of salt you have to swallow.
Meanwhile you've come to the right site for information and comradery for your dear Husband. Stay with us and keep posting!!!
Good Luck, Good Health and Good Humor.
j-o-h-n Tuesday 10/24/2023 6:21 PM DST
Zytiga failed, starting Xtandi. What to expect for my dad. 
Dad's Next Treatment?
Decision time – looking for opinions/advice please
