Anti-proliferative effect of Cannabidiol in Prostate cancer cell PC3

[NewPotatoCaboose]

More on CBD and prostate cancer

Anti-proliferative effect of Cannabidiol in Prostate cancer cell PC3 is mediated by apoptotic cell death, NF?B activation, increased oxidative stress, and lower reduced glutathione status

pubmed.ncbi.nlm.nih.gov/377...

Abstract

Prostate cancer is the second most frequent cancer diagnosed in men in the world today. Almost all prostate cancers are adenocarcinomas and develop from gland cells. We used the PC3 prostate cancer cell line, which is well studied and derived from a bone metastasis of a grade IV prostatic adenocarcinoma. Cannabidiol (CBD), a major non-psychoactive constituent of cannabis, is a cannabinoid with anti-tumor properties but its effects on prostate cancer cells are not studied in detail. Here, we found cannabidiol decreased prostate cancer cell (PC3) viability up to 37.25% and induced apoptotic cell death in a time and dose-dependent manner. We found that CBD activated the caspases 3/7 pathways and increased DNA fragmentation. Furthermore, we observed an increase of pro-apoptotic genes Bax, an increased level of reactive oxygen species, lower reduced glutathione level, and altered mitochondrial potential in response to CBD treatment leading to lower cellular ATP. Overall, our results suggest that CBD may be effective against prostate cancer cells.

[Maxone73]

normally I would say “cell lines and in vivo does not mean it works on humans” (unluckily)….but when we talk about cbd and thc…I feel I am…let’s say…way less rigorous! 😜😜😜

[Nfler]

it’s seems to b working for me, I do1-2ml/day along w ivermectin 2-4/days/week and psa continues to drop readily…def worth a try

[Maxone73 in reply to Nfler]

What concentration?? 😊

[Nfler in reply to Maxone73]

Ivm at 12 mg/day 4/days a week.

Cbd at 1-2 ml/day 6 days/week

[Maxone73 in reply to Nfler]

Yes, ok about ml but concentration? My oil here is 275mg per 10ml but there are different concentrations. Many express them just as percentage, like 10% cbd oil. I could also grow some plants in spring but I would prefer not smoking it!

[Nfler in reply to Maxone73]

Oh sorry, it’s500mg/10 ml, I get it from Lazarus naturals out of Oregon, high quality…

[Maxone73 in reply to Nfler]

I am not even sure I can find that concentration in shops here in Europe, but I will check!

[Nfler in reply to Maxone73]

Well order it from Lazarus, they give a 60% discount to low income and their the highest quality I found this far

[Maxone73 in reply to Nfler]

I will look into it, not sure that the customs would let me import it but you never know

[NewPotatoCaboose in reply to Nfler]

Lazarus is great! Been ordering from them for several years.

[dhccpa in reply to Nfler]

How many mg of ivermectin per day?

Never mind, I saw it.