Gout drug febuxostat may be useful as repurposed drug for CRPC

[Graham49]

The effects of febuxostat and allopurinol castration–resistant prostate cancer cells using CD44 as an indicator: possibility for the drug repurposing of febuxostat in castration–resistant prostate cancer

Authors: Yasuhiro Suzuki1, et al.

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Source: Therapeutic Research Volume 44, Issue 5, 363 - 368 (2023)

Publisher: ライフサイエンス出版

Abstract

Drug repurposing, is the re–tasking of known medications for new clinical indications. In this in vitro study, we evaluated the possibility of the drug repurposing of xanthine oxidase inhibitors (febuxostat and allopurinol) for treating castration–resistant prostate cancer. We used the castration–resistant prostate cancer cell line PC–3 to investigate the effect of xanthine oxidase inhibitors on the production of CD44, an adhesion factor and cancer stem cell marker. The CD44 mRNA expression levels were then evaluated by a real–time PCR. The results demonstrated that the application of febuxostat caused a concentration–dependent inhibition of the expression levels of CD44; a significant suppression occurred with the 100 μM concentration. The 15–min application of febuxostat without TNF–α treatment significantly suppressed CD44 mRNA and protein expression 24 hours after the 100 μM febuxostat treatment. The pretreatment with allopurinol did not decrease the expression of CD44 mRNA and protein expression without TNF–α. The production of CD44 in PC3 cells was suppressed by febuxostat treatment in this experiment, indicating a possibility for the repositioning of febuxostat.

[Spyder54]

Saved ! Thanks Graham

[j-o-h-n]

From Dr.Googlebird, (for general information):

Febuxostat is an inhibitor of the enzyme xanthine oxidase and is FDA-approved for the chronic management of hyperuricemia in patients diagnosed with gout.[1][2] Due to an increased risk of cardiovascular mortality with febuxostat versus allopurinol, the FDA recently recommended limiting the use of febuxostat to patients for whom allopurinol is not efficacious or who experience severe adverse effects with allopurinol. It is important to recognize that febuxostat is not approved for treating asymptomatic hyperuricemia.

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 11/21/2023 1:27 PM EST

[dhccpa in reply to j-o-h-n]

I'm going to read this aloud at the family get-together tomorrow.

[j-o-h-n in reply to dhccpa]

Read it after dessert.............

BTW this is off topic, but buy a can of crushed pineapples (with or without sugar) strain the crushed pineapple (drink juice later if you wish) and mix it with a can of whole cranberries. Refrigerate and serve as you would cranberry sauce with your turkey. Makes a great ice cream topping also and just as a delicious plain old dessert. Read this aloud also.....Happy Thanksgiving to all.....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 11/22/2023 11:07 AM EST

[dhccpa in reply to j-o-h-n]

Will do thanks!