Prolia 1yr Update

[TylexGP]

I wanted to share my Prolia results. One year ago my DEXA scan showed Osteopenia in the left femoral neck (T -1.1) and I started Prolia. I chose not to take Vitamin D or calcium as they were within normal range. My DEXA scan a year later showed a 3.5 % increase in bone density in my hip with a T of -0.9 and assessed as normal. I have an appointment with my MO next week and will plan to continue Prolia while my testosterone remains at castrate levels.

[Soumen79]

Hi

Its nice to hear a good response, good for you good for us. May I know the dosage? And how you planned to manage side effects if any?

🙏🙏

Soumen

[TylexGP in reply to Soumen79]

My Prolia dose is 60 mg every 6 months by Sub-Q injection in alternating arms. I deal with any side effects bu maintianing good dental hygiene with consistent routine dental prophylaxis. My dentist is aware I am on Prolia. I might have a few more aches and pains in my bones and joints but nothing significant and nothing I directly contribute to Prolia and more attribute it to getting older and abuse I subjected my body to in my youth.

[Soumen79 in reply to TylexGP]

Thank you so much for the valuable information.

[RyderLake2]

Hello,

I am a big fan of Prolia (denosumab). It was recommended to me ten years ago by my medical oncologist and I have been taking it ever since. I was diagnosed in 2013 with widespread bone metastases from my neck to my knees. The normal Prolia maintenance dose is a 60mg/ml syringe injected every six months subcutaneously. My family doctor likes me to have a creatinine test prior to each injection. No side effects that I am aware of. I personally think it is a better bone strengthening drug than Zometa (zoledronic acid) and others. It is easier to take and you don't have to monitor kidney function quite so regularly.

[Rocknlily in reply to RyderLake2]

So good to hear something positive, finally. I am a kidney transplant patient and they said it is the safest choice for me. But, I hear about and read bout all the side effects. I was told you can only stay on it for 2 years and have to switch?

[RyderLake2 in reply to Rocknlily]

Hello,

That has certainly not been my experience. Perhaps an explanation of how Prolia (denosumab) injections work might be helpful. Bones are constantly changing. There are special cells in the body called osteoclasts whose primary function is to remove bone. There is another type of cell called osteoblasts, which are bone forming cells. In normal bone structure, there is a balance between the actions of these two cells. In people with osteoporosis, this balance no longer exists. It is the same thing with men suffering from prostate cancer who take drugs that stop the production of testosterone. In both cases, the cells that remove bone work overtime, removing bone faster than new bone can be created. The result is bones that are thinner, weaker, and more likely to break. Prolia works differently than other osteoporosis medications. It is a RANK ligand inhibitor. RANK ligand is a protein which activates the cells that break down bone (osteoclasts). Prolia blocks RANK ligand to stop the cells that break down bone. This action strengthens your bones by increasing bone mass and lowers the chance of breaking bones of the hip, spine and other sites. My family doctor injects one single-use refilled syringe every six months. I also take calcium and Vitamin D for bone strength. Give it a try! Good luck! 🙂

[Hidden]

I went from -1.1 left femur neck also to -0.7

But I went with the walk-in with weights and resistance exercises. Added in some Calcium along with D3, K2 Mk7. and Magnesium.

Exercise took care of the ADT depression you brought up a while back.

Im reserving denosumab if I ever get bone mets. IF!!!

[TylexGP]

That is great progress. I am still active and excercise; my new favorite excercise is chain saw carving. It works my body and mind and the focus required takes me away from the ADt rabbit holes and I truly enjoy it.

[j-o-h-n in reply to TylexGP]

How much would you charge to chain saw carve my ex-wife? (member discount?)

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 07/13/2023 10:19 PM DST

[TylexGP in reply to j-o-h-n]

Always a member discount!😃

[LifeQuality in reply to j-o-h-n]

Gosh I love you, j-o-h-n!

[j-o-h-n in reply to LifeQuality]

O WOW.....does that mean we're going steady?

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 07/16/2023 6:44 PM DST

[GSDF in reply to j-o-h-n]

😅😅😅😅😅

[Grandpa4]

you can not stop Prolia abruptly. It causes a major drop on bone density. You can take a year or maybe 6 months of alendronate and then try stopping.

[dhccpa in reply to Grandpa4]

Is that for anyone on Prolia, or just if you've had fractures? Seems like TA weighed in on this a while back, but I'm fuzzy on his exact answer.

[wilcoxsaw in reply to Grandpa4]

Do you have any data you can share supporting this? If so please share. Thank you.

[pe43 in reply to wilcoxsaw]

Here is a long review of this:

Discontinuing Denosumab: Can It Be Done Safely? A Review of the Literature

ncbi.nlm.nih.gov/pmc/articl....

The authors give a short summary: "The discontinuation of denosumab may potentially be risky, as the rapid reversal following cessation leads to a rebound in bone turnover with subsequent bone loss and a possibility of multiple vertebral fractures."

[wilcoxsaw in reply to pe43]

Thank you!