Foundation One No Results

[Lawrencee]

Had a blood draw for a Foundation One test. Test center got back with Onco and commented not enough DNA for an adequate test. Guess I am confused. Can anyone explain?

[Tall_Allen]

The Foundation One blood test looks at the DNA in your blood from tumor cells. The problem is that tumors don't reliably slough off cells. That's why I prefer tests of tumor tissue.

[Lawrencee in reply to Tall_Allen]

Does this require a biopsy of the tumor?

[Tall_Allen in reply to Lawrencee]

Yes

[JrTOO in reply to Tall_Allen]

Liquid biopsies are state of the art 2023! Inform me if LBs are unreliable! Puleez.

Cf. MD Anderson mdanderson.org/cancerwise/l...

[Tall_Allen in reply to JrTOO]

I said "The problem is that tumors don't reliably slough off cells. That's why I prefer tests of tumor tissue." So if the cancer tumors aren't shedding DNA, there is nothing for a blood test to pick up. Whereas, as somatic test will always be able to look at cancer cells as long as the tumor is big enough to sample. The trade off, is that the blood test is an average of all your tumors, whereas a somatic test can only sample one tumor at a time (it's a good idea to biopsy more than one).

[j-o-h-n]

shit, another freaking biopsy!!!

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 05/06/2023 6:40 PM DST