Foundation One partial report

[JolleySprings]

Anyone knowledgeable about this? If I understood correctly, I read a low mutational burden was not good! 😩😩😩😩😩 And CDK12 is rare.

[NotAlwaysSunshine]

I know of one person that has this. I'll text and see if they will respond.

[JolleySprings in reply to NotAlwaysSunshine]

Thank you! I would very much appreciate! I have also looked under topics & files. Very little there!

[NotAlwaysSunshine in reply to JolleySprings]

I know the feeling... husband is RAD51c

[Tall_Allen]

Actually, the opposite is true - low mutational burden means that your cancer is not mutating rapidly. It is only a benefit in that some immunotherapies can help if it is highly mutated.

There are some trials for CDK12:

clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

[JolleySprings in reply to Tall_Allen]

Thank you so much for the comment! The oncologist says he doesn’t qualify Yet for Trial bc his PSA has been setting at .9 For 4 months … and he has only taken Lupron/Casodex thus far. Is this accurate about qualifying for a trial???

[JolleySprings in reply to JolleySprings]

Also TA…. Would there be a benefit to having a Circulating Tumor Blood Test? The Foundation One report came from original tissue at surgery which was 5 years ago in 2017.

[Tall_Allen in reply to JolleySprings]

You may want to save that for later when there are more metastases and more tailored therapies available.

[john4803 in reply to Tall_Allen]

TA, I specifically asked my MO about this, 2 weeks ago and he said our cancer will most likely be different from the original biopsy. My prostate was removed in November of 2017 and coming up on 5 years. From my understanding, it is routine to do genomic sequencing immediately, once Breast Cancer is confirmed. Why do they not do that with Prostate Cancer?

[Tall_Allen in reply to john4803]

The OP has low mutational burden indicating it is not evolving quickly. He already had one Foundation One report. At some point, insurance will say - no more.

[Tall_Allen in reply to JolleySprings]

You have to check the inclusion and exclusion criteria in each of those links.

[j-o-h-n in reply to Tall_Allen]

You may be a pita sometimes, but you do know your shit and we all appreciate that..... Thanks...

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 06/29/2022 7:22 PM DST

[Tall_Allen in reply to j-o-h-n]

You may be a gyro sometimes, but you do tell jokes and we all appreciate that.

[JolleySprings]

Thank you!!!

[joeguy]

Its interesting that RAD51C is now "disease relevant". When my genetic test came back with that variant, it said "uncertain clinical significance"...... guess its significant now.

[KocoPr in reply to joeguy]

How do you find out if your “uncertain significance “ becomes significant?

I have RAD50 uncertain significance as of my gen seq test in march 2020

[joeguy in reply to KocoPr]

Not sure..... when I search for the one I have, it shows up relative to other cancers, but not prostate cancer