Published online 2018 Apr 13. doi: 10.4103/aja.aja_14_18
PMCID: PMC5952478
PMID: 29667615
Vitamin D in prostate cancer
Donald L Trump and Jeanny B Aragon-Ching
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Abstract
Signaling through the vitamin D receptor has been shown to be biologically active and important in a number of preclinical studies in prostate and other cancers. Epidemiologic data also indicate that vitamin D signaling may be important in the cause and prognosis of prostate and other cancers. These data indicate that perturbation of vitamin D signaling may be a target for the prevention and treatment of prostate cancer. Large studies of vitamin D supplementation will be required to determine whether these observations can be translated into prevention strategies. This paper reviews the available data in the use of vitamin D compounds in the treatment of prostate cancer. Clinical data are limited which support the use of vitamin D compounds in the management of men with prostate cancer. However, clinical trials guided by existing preclinical data are limited.
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Magnus1964
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I try to get at truth. It is fortunate that there have been 3 major randomized clinical trials to find out what is true. I would certainly prefer that some inexpensive, readily available substance would be beneficial, but I prefer to know what is true than to pretend my biases are confirmed.
During my proton radiation therapy it was recommended for me to stop taking my anti oxidants. Vit D is considered an anti-oxidant. I will resume my regiment of vitamins after treatment is finished in three weeks.
Form the Mayo clinic- Vit D - Its anti-inflammatory, antioxidant and neuroprotective properties support immune health, muscle function and brain cell activity.
I know you have no knowledge of biochemistry, but what do you suppose most hormones are? e.g., testosterone, cortisol, estrogens, progesterones, etc - they are BOTH hormones and steroids.
So what if it can? "Can" doesn't mean "it has." In fact, steroids have far-ranging effects in our bodies and interact in complex ways. Anic et al. (below) showed there was a positive association between serum Vitamin D level and the amount of serum testosterone - not an effect that a man who is taking androgen deprivation wants.
I concur with you that the epidemiological information or common knowledge coming via shared experiences and can be very useful, and in particular when it involves supplements handled with care.
Scientific knowledge in any case is only the best or rather generally accepted knowledge and is only good until its debunked by a new paradigm
Good doctors sometimes can hint at indications that a new paradigm is going to replace the current one and make a difference in our chances of survival an QOL
The essence of science is skepticism and hypothesis-testing. It is also consensus by experts. Experts can and do challenge low level evidence. But you are no expert, and have no business challenging what you do not even begin to understand (see: "the Dunning-Kruger Effect").
If you want to understand how science works, read this:
That's called a strawman argument- you make up what someone else believes and then you refute the nonsense you just made up. Here's what I actually think medical science is - do you have another idea?
My website has links to actual evidence. I could copy and paste it all here, but it is easier to provide a link.
There is nothing circular in my logic. Circular logic is when one accepts a premise based on the conclusion; e.g., A (the conclusion) is true because B (the premise) is true, and B is true because A is true.
My MO said to me 5 years ago to use sunshine. We are not against vitamin D but I want the most natural source.
I am also taking vitamin D supplement but I am aware that it may not be the most ideal source. I am not a doctor but that is what my MO told me when I asked him about taking vitamin D supplements.
My vitamin D levels are at the minimum now so maybe I have to supplement if I will be deficient.
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