Vitaman D and Prostate Cancer

[Magnus1964]

Asian J Androl. 2018 May-Jun; 20(3): 244–252.

Published online 2018 Apr 13. doi: 10.4103/aja.aja_14_18

PMCID: PMC5952478

PMID: 29667615

Vitamin D in prostate cancer

Donald L Trump and Jeanny B Aragon-Ching

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Abstract

Signaling through the vitamin D receptor has been shown to be biologically active and important in a number of preclinical studies in prostate and other cancers. Epidemiologic data also indicate that vitamin D signaling may be important in the cause and prognosis of prostate and other cancers. These data indicate that perturbation of vitamin D signaling may be a target for the prevention and treatment of prostate cancer. Large studies of vitamin D supplementation will be required to determine whether these observations can be translated into prevention strategies. This paper reviews the available data in the use of vitamin D compounds in the treatment of prostate cancer. Clinical data are limited which support the use of vitamin D compounds in the management of men with prostate cancer. However, clinical trials guided by existing preclinical data are limited.

[Tall_Allen]

Fortunately, there have been 3 major randomized clinical trials since then proving no effect.

[jbskiatook in reply to Tall_Allen]

Thanks for giving us your knowledge.

[Magnus1964 in reply to Tall_Allen]

"Fortunately"? Do you enjoy trying to debunk complimentary medicine?

[Tall_Allen in reply to Magnus1964]

I try to get at truth. It is fortunate that there have been 3 major randomized clinical trials to find out what is true. I would certainly prefer that some inexpensive, readily available substance would be beneficial, but I prefer to know what is true than to pretend my biases are confirmed.

[anonymoose2 in reply to Tall_Allen]

Yes but did they include broccoli broth within that study? Cheers 🥂

[BB_1]

During my proton radiation therapy it was recommended for me to stop taking my anti oxidants. Vit D is considered an anti-oxidant. I will resume my regiment of vitamins after treatment is finished in three weeks.

[Tall_Allen in reply to BB_1]

Vitamin D is not an antioxidant, it is a steroid.

[CAMPSOUPS in reply to Tall_Allen]

Just what one needs lol. Haphazardly throw a steroid into the mix of genetic, biochemical and drug environment of treating our cancer.

[BB_1 in reply to Tall_Allen]

Form the Mayo clinic- Vit D - Its anti-inflammatory, antioxidant and neuroprotective properties support immune health, muscle function and brain cell activity.

[Tall_Allen in reply to BB_1]

Good reason to avoid it unless one has a deficiency.

[Magnus1964 in reply to Tall_Allen]

Cancer patients do have deficiency.

[Tall_Allen in reply to Magnus1964]

What makes you say that? Have you seen a trial that proved that? I've never had a Vitamin D deficiency.

[Magnus1964 in reply to Tall_Allen]

My doctor told me. Plus you need Vitamin D to process calcium for bone loss which occurs in prostate cancer. In addition the NIH.

doi: 10.3892/etm.2011.205

PMCID: PMC3440651

PMID: 22977487

Prevalence of serum vitamin D deficiency and insufficiency in cancer: Review of the epidemiological literature

DIGANT GUPTA, PANKAJ G. VASHI, KRISTEN TRUKOVA, CHRISTOPHER G. LIS, and CAROLYN A. LAMMERSFELD

[Magnus1964 in reply to Tall_Allen]

Vitamin D is a hormone NOT a steroid.

[Tall_Allen in reply to Magnus1964]

I know you have no knowledge of biochemistry, but what do you suppose most hormones are? e.g., testosterone, cortisol, estrogens, progesterones, etc - they are BOTH hormones and steroids.

[Magnus1964 in reply to Tall_Allen]

Yes you are correct. However, steroids can lower vitamin D3 levels leading to deficiency.

[Tall_Allen in reply to Magnus1964]

So what if it can? "Can" doesn't mean "it has." In fact, steroids have far-ranging effects in our bodies and interact in complex ways. Anic et al. (below) showed there was a positive association between serum Vitamin D level and the amount of serum testosterone - not an effect that a man who is taking androgen deprivation wants.

ncbi.nlm.nih.gov/pmc/articl...

It is easy enough to check your serum Vitamin D level - and only supplement if you are deficient.

[Rickmartin1948]

I concur with you that the epidemiological information or common knowledge coming via shared experiences and can be very useful, and in particular when it involves supplements handled with care.

Scientific knowledge in any case is only the best or rather generally accepted knowledge and is only good until its debunked by a new paradigm

Good doctors sometimes can hint at indications that a new paradigm is going to replace the current one and make a difference in our chances of survival an QOL

[Tall_Allen in reply to Rickmartin1948]

Without science, your "good doctor" is just a witch doctor.

[Rickmartin1948 in reply to Tall_Allen]

hahaha TA do not be an extremist

Good Doctors know their boundaries

[Tall_Allen in reply to Rickmartin1948]

Very strange and possibly dangerous to one's health to call science "extreme"

[Magnus1964 in reply to Tall_Allen]

Science is not to worshiped, science is to be tested in light of new evidence. Never trust science, challenge it.

[Tall_Allen in reply to Magnus1964]

The essence of science is skepticism and hypothesis-testing. It is also consensus by experts. Experts can and do challenge low level evidence. But you are no expert, and have no business challenging what you do not even begin to understand (see: "the Dunning-Kruger Effect").

If you want to understand how science works, read this:

prostatecancer.news/2022/07...

[j-o-h-n]

Just the facts...............

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 04/29/2023 10:36 PM EST

[Justfor_]

For those preferring viewing from reading:

youtube.com/watch?v=YjtROU1...(Not working as expected?)

PS: At the time of posting I wasn't aware that this link had already been posted here: healthunlocked.com/advanced...

[hansjd in reply to Justfor_]

Thank you for this post !

[Rickmartin1948]

Nothing is fixed in science, just the latest accepted

[Tall_Allen in reply to Rickmartin1948]

"... just the latest accepted" But who gets to decide what is accepted - you or experts in the relevant field?

[Tall_Allen]

That's called a strawman argument- you make up what someone else believes and then you refute the nonsense you just made up. Here's what I actually think medical science is - do you have another idea?

prostatecancer.news/2022/07...

[Magnus1964 in reply to Tall_Allen]

You keep referencing your own website, that is circular logic. I know because here is the evidence I wrote.

[Tall_Allen in reply to Magnus1964]

My website has links to actual evidence. I could copy and paste it all here, but it is easier to provide a link.

There is nothing circular in my logic. Circular logic is when one accepts a premise based on the conclusion; e.g., A (the conclusion) is true because B (the premise) is true, and B is true because A is true.

[Seasid]

My MO said to me 5 years ago to use sunshine. We are not against vitamin D but I want the most natural source.

I am also taking vitamin D supplement but I am aware that it may not be the most ideal source. I am not a doctor but that is what my MO told me when I asked him about taking vitamin D supplements.

My vitamin D levels are at the minimum now so maybe I have to supplement if I will be deficient.

[Tall_Allen in reply to Seasid]

As long as serum level is ≥ 20 ng/ml, you are fine.

aafp.org/pubs/afp/issues/20...

[Magnus1964 in reply to Tall_Allen]

My Research doctor recommended at least 30 ng/ml.

[jfoesq]

Once Again- Tall_Allen speaks with truth, science and accuracy and corrects those who just don't understand both science and logic.