PSA rising slowly since Nov 2022

[Ian996]

PSA was 10.4 in April 2021 A PSMA Pet scan showed 3 mets on T9 T10 and L1

and started Zolodex in may

I had 3 mets treated with SBRT in late june 2021 by August my PSA dropped to 0.1

and dropped agin in October to0.07 but by Dec 2021 there was a slow but steady increase

doubling every 4 weeks, By May 2022 PSA was up to1.44

Started takingXtandi in early June 2022 and PSA dropped to 0.40 by July then down to 0.27

in November However since January it has been slowly increasing Yesterdays PSA test was 0.41

A recent CT scan shows new lesions on T4 and T11

I am having another PSMA Pet scan at the end of this month pending the results of the scan am I looking at more SBRT? or am just playing whack a mole?

[Tall_Allen]

Talk to your oncologist about Zytiga.

[Ian996 in reply to Tall_Allen]

back to my original question. Is SBRT the right way to go? will the cancer load be reduced so I have a chance for the drugs to work or am I just resistant to Xtandi after only 9 months

[Tall_Allen in reply to Ian996]

IDK if whack-a-mole accomplishes anything - the jury is still out. I do know that hormone therapy works. If you want to zap 'em, and if it's safe to do so, why not? But don't be deceived by the lower PSA to withhold hormone therapy.

[Ian996 in reply to Tall_Allen]

I realize that the jury is still out on SBRT , wack a mole but I fear I don't have enough time for the jury to come in. I will stay on ADT and Hormone therapy but having the drugs losing their effectiveness in such a short time is very very unnerving

[Tall_Allen in reply to Ian996]

It doesn't make them last longer if you stop using them.

[Ian99]

For info I have been on Zoladex since 8/21 and Zytiga since 1/22. I find them tolerable. They seem to have halted met growth judging from scan compares, so far at least.

[treedown]

I am at a similar point for that decision. I think I am at the wack a mole point but the idea of having lesions on my upper spine makes me want to knock them down if possible. I might think differently if they were elsewhere but thats just speculating. I am also off ADT and coming back on after first recurrence so want to start with as clean of a slate as I am able and this is all my PET scan could find. My RO told me about a new machine being developed. A PET scan/ radiation delivery all in one. The PET scan would find the lesion and apply radiation to the lesion at the same appointment. He said this is wack a mole of mets is becoming common with other cancers as well. So I guess from what little I know, if its safe and insurance/state will pay why not.

[BMRboy in reply to treedown]

After experiencing my third recurrence, I am scheduled for another PSMA scan at City of Hope in Duarte, CA next Monday. I have also been asked to participate in a study where I will have a second PSMA scan on the new RefleXion PET CT/radiation machine they have on the same day if any mets are detected on the first scan. Although this new machine has been approved for use on lung and bone mets for other cancers, my radiation oncologist is hoping this study will help lead to FDA approval for its use in prostate cancer. Google RefleXion.com for more info in this new machine.

[treedown in reply to BMRboy]

So that sounds like what my RO mentioned. Are you in the US?

[BMRboy in reply to treedown]

Yes, I am located in the Los Angeles, California area in the USA.

[treedown in reply to BMRboy]

That makes sense. I would love to hear how that goes. Even a better a pic of the machine if your able. Sounds like science fiction compared to how things were when I was diagnosed.

[BMRboy in reply to treedown]

Sorry, not sure how to post the link here. See Reflexion.com and their press releases for more info and photos of the machine.

[treedown in reply to BMRboy]

Sounds good. Thanks.

[j-o-h-n]

Stop with this whack-a-holey..........it's bringing back memories of pleasure...........

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 03/12/2023 7:58 PM DST