nubeqa only for non metastatic?

[Spring15-3]

I was just reading here that nubeqa is approved only for non metastatic castration resistant. Husband had horrendous reaction to xtandi so they switched him to nubeqa but he has 2 bone mets? Should this have happened? What are better options?

[Oldie68]

That is incorrect. Nubeqa is approved in the US for metastatic CSPC based on the ARASENS clinical trial.

[KocoPr]

im castrate sensitive and on nubeqa. It is a great Androgen Receptor Inhibitor. If you use the search engine I have posted a few times with very good articles on it and it’s resistant pathways

[Tall_Allen]

It is approved for non-metastatic CRPC or, along with docetaxel for mHSPC. Oncologists may prescribe it off-label for other situations.

[Concerned-wife]

you can read many experts taking about daraludamide on UroToday. It sounds like an excellent choice.

[Survivor86]

After rising PSA and PET scan revealed mets to my upper spine and right femur, my Dana-Farber MO (and RO) recommended SBRT (five days) along with 24 months of Lupron and Xtandi for my mHSPC. Within a month of SBRT, PSA was undetectable. PSA remained undetectable but by end of six months I could no longer tolerate extreme fatigue, mood swings and other side effects of Xtandi. MO recommended switching to Nubeqa (darolutamide) which I then took in combination with Lupron for the next 18 months. Side effects of Nubeqa were relatively mild. I completed 24 month course of ADT plus 6 months of Xtandi and 18 months of Nubeqa 10/22 and am happy to say that PSA remains undetectable. So far, so good. I am now 74, 7.5 years into this journey, and feel very fortunate.

[CurrentSEO in reply to Survivor86]

Hi, what is your testosterone level now?

[Spring15-3 in reply to CurrentSEO]

it went from 5.89 to 8.05 to 7.38

[CurrentSEO in reply to Spring15-3]

fingers crossed then , that when testosterone is back, PSA remains undetectable 👍

[Spring15-3 in reply to CurrentSEO]

question. The doc seems to think nubeqa isn't working because psa went up but you're saying basically undetectable? I'm confused..don't really have a lot of faith in the doc

[CurrentSEO in reply to Spring15-3]

please RE-read survivor86 message to whom my original reply was

[Spring15-3 in reply to CurrentSEO]

oh lordy..so sorry

[Survivor86 in reply to CurrentSEO]

<3

[Survivor86 in reply to CurrentSEO]

<3

[podsart]

When I had to get off Xtandi, my Dr insisted I had to try Erleada first before he could begin to fight for me to get Daralutamide, which is what I wanted to take after Xtandi. I see there are many that have been able to get directly to daralutamide

[Meshel48]

My husband was on 5/2021 Zytga and prednisone Lupron and Xgeva his PSA was 3,340.00 Then 6/25/2021 15.0 Then 8/25/2021 1.4 Then 11/16/21 0.37 then it started going up so they switched to xtandi it brought it down but only for a month so switch to chemo Taxotere barley made it thru 3 of those and now is on pluvicto. Two treatments so far.Praying for good results for you .

All the ADT treatment gave him horrible side effects but they lowered his PSA . HBP High Blood Sugar Hot Flashes loss of muscle weakness tired sleeps all the time. When he was first went in it was thru emergency he had a burst fracture of T5 stage IV Prostate cancer Bone metastases.

[Spring15-3 in reply to Meshel48]

thank you. Hope it all works out for you too! Husband is going through all of those side effect with the lupron and nubeqa. Xtandi was a nightmare, he basically acted like he had alzheimers when he was awake but he slept probably 18 hours a day or more.