Prolia vs Reclast for bones

[Scout4answers]

My MO has offered me a choice.

Prolia shot every 6 months vs Reclast infusion once / year.

Do both have the same potential for jaw problems?

You experiences appreciated...

[Scout4answers]

This site has such a wealth of info, The post below popped up to the right as being of potential interest when I posted my question:

healthunlocked.com/advanced...

[cesanon in reply to Scout4answers]

It would be nice if you end up getting some evidence based confirmation of that proposition on the use of denosumab (XGEVA, Prolia) as a prophylactic against the spread of prostate cancer to the bone.

[Grandpa4 in reply to cesanon]

ncbi.nlm.nih.gov/pmc/articl...

[cesanon]

Please don't forget to post what conclusion you come to.

[Tall_Allen]

From what I've read, anything less than monthly is no better than nothing.

"And we did an analysis looking at different centers in Canada, some that give every three months and some that give every four weeks, and we saw that patients that were getting it every three months that needed it, were actually having almost the same event rate as patients not treated at all."

urotoday.com/video-lectures...

[HikerWife in reply to Tall_Allen]

Very informative, thank you.

[cesanon in reply to Tall_Allen]

So higher frequency is better?

How high a frequency are they willing to give?

[tango65]

The risk of osteonecrosis of the jaw is not very different between denosumab and zoledronic acid.. The risk is low and ONJ usually happens in people who have inflammatory processes in the teeth because of infeccion or because they require tooth extraction or other surgical procedure.

jamanetwork.com/journals/ja...

Both are effective to control osteoporosis.

Zoledronic acid may affect the kidneys and it may cause an acute phase reaction with fever, fatigue, muscle pain etc, usually in the first 72 hours.

accessdata.fda.gov/drugsatf...

These drugs in the context of prostate cancer are used to treat osteoporosis in hormone sensitive cancer and to prevent adverse skeletal events, mainly pain and fractures in mCRPC.

[cesanon in reply to tango65]

"The risk of osteonecrosis of the jaw "

I must say that is a real issue for me. Especially as I grow older I have more teeth issues.

Once you take this stuff, you are really at risk for many years if you need dental work.

[Pte82]

Scout4answers, geranylgeraniol has shown an ability to improve the side effects of bisphosphonate therapy by regulating the mevalonate pathway in addition to having a suppressive effect on prostate cancer. When teamed with annatto tocotrienol's effects on prostate cancer, in addition to being a bone builder, it creates a synergy worth investigating. Always consult with your health care professional before using any supplement.

[maley2711]

You will be using one of those to combat the negative impact of the ADT on bones? are you osteopenic..hopefully not osteoporosis. Not actually used for reducing metastatic growth, is it?

[Concerned-wife]

just adding this excellent article to the discussion since Fred Saad was involved and it is 2921. cua.org/system/files/Guidel...

The routine use of bone-targeted therapies has not been shown to prevent skeletal metastasis or reduce SREs in men with metastatic CSPC.43 The CALGB 90202 study deter- mined that early treatment with zoledronic acid in meta- static CSPC was no different than placebo in preventing fractures or improving survival.44 Similarly, zoledronic acid with and without docetaxel showed no improvement in SREs in the STAMPEDE trial.45 Finally, the ZAPCA trial found no difference in time to treatment failure or first SRE when comparing zoledronic acid to placebo.46 Therefore, at this time in metastatic CSPC, bone-targeted therapies are only indicated in men who are at increased risk of

[thudson1965]

You may want to sign up for the American Bone Health: Osteoporosis forum.

healthunlocked.com/american...

I posted this in Feb 2022.

healthunlocked.com/american...

My endocrinologist said that Reclast can be used for 10 years before switching.

I took Reclast in 2019 at age 54 and in 2020. My bone density improved enough in my 2022 done density scan (DEXA), that my next scan is in 2025 - 3 years.

healthunlocked.com/american...

You can search for Reclast by using the "Search HealthUnlocked" in the upper right corner

healthunlocked.com/search/p...

[cesanon]

Weight bearing exercise is always and option. Or a supplement.

[efsculpt]

I had Prolia shot every 6 months for 2 years while on Lupron, Zytiga, Prednizone. No bone loss. I had dental work done 2 years later, plus a root canal 2 1/2 year after last shot. Jaw OK.

Craig

[j-o-h-n]

M.O. to you," time to play, Let's make a deal":

Do you want what's behind curtain number 1?

-or-

What's behind curtain number 2?

If you wish we can also play "Lets make a deal".

"So come on down!"

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 02/17/2023 5:48 PM EST