I've been on Eligard for four years and have developed osteoporosis and osteopenia. My urologist and MO had recommended that I take Prolia treat the one density issues. I have read a lot of negative comments on the internet concerning the serious side effects of the medication. Most recommend that one should not take the drug if possible since quality of life will be affected. My doctors have disagreed and I decided to take the injection which I did two days ago.
What is the experience of members of this board?
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tmpascale
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Older women with bone issues and also men with nonmetastatic prostate cancer who are on androgen deprivation therapy (ADT) are sometimes given Prolia (denosumab) to help maintain bone health. Look at this link for the sections that mention men with prostate cancer, and the related clinical trial studies that supported the FDA approval of Prolia for those indications.
On the other hand, men with metastatic prostate cancer that has spread to bones are often given a more frequent treatment with Xgeva (denosumab), which has the same active ingredient, but is used in a different context. For similar details, see:
Many oncologists also offer another drug IV called Zometa (zoledronic acid) for similar purposes, involving a different chemical mechanism, but for similar end results.
If you are doing a zometa like drug anyway, add Celebrex. Very few negative side affects and recent studies showed the two together (tho neither alone ) reduced deaths by over 20%. Look at some of Tall Allen’s posts for the details. He’s the one that pointed it out to me.
That I can not say for sure. I’d ask Tall Allen tho. He’s one of the most knowledgeable guys on this site and he’s the one that showed the Zometa/Celebrex study to me.
I, like many of the above, have used Prolia with no negative side effects. On the contrary, i have fallen 3 time that I can remember, and no bone issues. In fact, the clinic did a Dexa scan and found some osteopenia before my first Prolia shot. Two years later, did another scan, and the osteopenia was gone. I was amazed, so were my doctors.
There are bad things that can happen, but they are so rare I do not worry about them, or I take care to avoid them. I do strongly recommend the drug based on my own personal experience, nothing else. I am NOT medically trained.
I used Xgeva for poor bone density with no side effects during the3rd and forth year. I had 1 shot every 6 months for 1 1/2 years. Watching calcium levels and Vit D3 levels are also equally important. I was using 3000 IU Vit D3 daily and still I had no "reserve" of Vit D3 in my body. This made me tired. So my doctor gave 50,000 units once a week for 13 weeks. Do not do this on your own, ask your physician. There is a lot of Vit D3 stored in the kidneys. When your doctor does a CBC (complete blood count) ask about these things and remember to just keep truckin'.
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Prolia=Exgeva ???
Lupron, Prolia and Creakiness
Prolia
QoL: Hospice experience 
Bone loss - loss of flexibility, can’t tie up shoe lace - Denosumab (Prolia)
