First injection of Lu177-PNT2002 as part of SPLASH trial

[joeguy]

I just received the first injection of Lu177 on 11/10/22. So far the side effects have not been bad. Fatigue has been the primary SE, along with headache. The fatigue is probably worse than what comes with ADT, but still very tolerable. There have luckily been no issues with nausea or diarrhea . Some of the areas with bone Mets are also hurting. Not sure if that might be from the drug attacking the cancer ? I was directed to discontinue Darolutimide, so the only hormonal drug I will be on is Orgovyx while I am in the trial. I feel very fortunate to have gotten into the SPLASH trial when I did, because I was told the trial just closed last week. Hoping they learn from guys like me that earlier use of Lu177 before chemo has an increased therapeutic benefit.

[Tall_Allen]

Inflammatory pain in bone metastases is common following radiation. Good luck!

[joeguy in reply to Tall_Allen]

thanks Allen, hoping for a great response

[ARIES29]

I did not have any SE on my first LU-177 either but the second one was different for me anyway.

[joeguy]

Aries,

what happened after your 2nd ?

[Ramp7]

I completed 6 infusions and was chemo naive. Side effects tolerable. I found hiking a lot complemented the therapy well. PSA dropped from 8.1 to 0.19. Lymph node in groin stable. Metastases on L4 stable. One small hot spot on tail bone scheduled for radiation. I too feel very fortunate to have landed in the trial at Dana Farber. A very special bunch of people. All the best to you

[joeguy in reply to Ramp7]

How long has it been since you completed your infusions? is your PSA remaining steady at .19 ? sounds like an excellent response

[Ramp7 in reply to joeguy]

Completed the cycle in October. Final PSA 0.50. A small area still active on my tail bone. Radiation scheduled,

[joeguy in reply to Ramp7]

Hoping it keeps your PSA low for a long time. Do they still have you on some form of hormone therapy?

[Ramp7 in reply to joeguy]

Yes, still taking 3 month Lupron shots. Have an appointment with Regular MO, for E2 low dose patch.

[Yank66]

Thanks for posting your experience. Please continue to do so. DH is waiting on appointment to get started at the University of Virginia.

[leo2634]

Thank you for your sharing your experience. The best of luck to you My friend. Never give up Never surrender. Leo

[joeguy in reply to leo2634]

thanks leo

[Ollie1948]

Hang tough Joe.... Probably I will be there shortly

[Daddyishealing]

Is this used post extensive chemo? In the US is it still only in trial. I thought fir some reason that it was available now

[Daddyishealing]

Best of luck. Ty for this info

[joeguy]

a slightly different version of this drug is approved for use after chemo in the US, it’s called Pluvicto

[Flyfisherbug]

Congratulations and good luck on the trial. I just missed it, so will be following you closely and hoping for another trial soon.

[joeguy in reply to Flyfisherbug]

Thanks, hopefully more drug companies will have different variations they create trials for soon

[u302000]

joeguy

Would your consider sharing your path to current treatment with LU177?

healthunlocked.com/advanced...

I am am just entering a Clinical trial, OK.

Cheers,

Buddy

[u302000]

Joeguy,

It has been 9 months now , how has it worked.

[joeguy in reply to u302000]

I was kicked out of the trial after scans and PSA showed progression after the first dose. My Drs in Tulsa think it was premature, and the Lu177 was actually starting to work. They say a flare is not uncommon.