Mushrooms: I have started chemo and... - Advanced Prostate...

Advanced Prostate Cancer

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Mushrooms

spencoid2 profile image
77 Replies

I have started chemo and will have a guided mushroom trip real soon. The therapist recommended taking lion's mane with niacin before during and after the trip. I think I would like to take mushroom supplements for the duration of the chemo. When I did radiation I took either turkey tail extract or a blend, forget which but at the time I was believing the Oriveda line that both hot water and alcohol are needed to get a good yield and that only mycelium has a high enough concentration to be worth extracting. Now their information is somewhat different and confusing. Also a little less technical information than in the past. Different mushrooms seems to be extracted different ways

I am trying to determine which is the best mushroom/brand/ extraction method for taking during chemo and also during the soon upcomoing trip. I can get different ,mushrooms for each?

77 Replies
Lulu700 profile image
Lulu700

I’ve taken QOL labs immunoKinoko 750 ahcc with acylated alpha- glucans per my Nat onco for 7 yrs . Best of luck on the majic mushroom trip . I did it as a teen in the 70’s and probably ten times as an adult . I’ve got some in the cupboard . Maybe I’ll do it by the fire during the holidays ? Mushrooms are great . I love wild mushrooms . Take care

So i can recommend ayahuasca to the open minded. A form of spiritual healing that helped me during this pc life . 🤙🏽🏄🏻‍♂️🏄🏻‍♂️🏄🏻‍♂️🏄🏻‍♂️🏄🏻‍♂️🏄🏻‍♂️

spencoid2 profile image
spencoid2 in reply to Lulu700

yes on Monday next a major mushroom trip. Was trying to find a suitable Lion's Mane or other supplement to highlight the trip and for immune support in chemo.

Lulu700 profile image
Lulu700 in reply to spencoid2

Free your mind! ✌️

WSOPeddie profile image
WSOPeddie in reply to spencoid2

Tell us more about this guided trip. Are you having to travel? To Oregon? How did you make arrangements? Is there a web site to facilitate this? How about the cost? I'm just full of questions, aren't I. I've seen the documentaries and I am very interested.

Lulu700 profile image
Lulu700 in reply to WSOPeddie

Come to my house and we will shut the gate and do em in my back yard surrounded by nature ! No neighbors to interfere ! 😳🍀

Kaliber profile image
Kaliber in reply to Lulu700

yes yes my amigo … psilocybin has an enormous anecdotal knowledge base of helping people in numerous ways. Mental uplift and depression curing being the top applications. They are a great party favor as well. Guaranteed to keep everyone in stitches laughing for an hour or two. They are being decriminalized and legalized in places like Oregon and Colorado and Oakland, California. The public just starting to realize how important they are.

I raised the small northern pacific coast species, in wide mouth mason jars , for several years. Probably produced several hundred pounds in that time span. This was in Central Texas back in the mid 70s. They are very easy to grow at home with todays simplified methods and supplies. Everything you need is available on Amazon and spore prints are sold in Oakland, and Canada on line. Dried in the oven or one of those plastic dehydrators that sit on a kitchen countertop …. then vacuum packed with a foodsaver and stored in a freezer they keep for years. These are ‘ extremely “ bitter to the taste but well worth it. The “ high “ is very pleasant , fairly mild, laugh inducing and not scary at all ( imho ).

Just say’in

cesces profile image
cesces in reply to Kaliber

"Everything you need is available on Amazon and spore prints are sold in Oakland, and Canada on line. "

I (and probably others here) would like to try psilocybin.

Do you have more specific details?

Thank you

Kaliber profile image
Kaliber in reply to cesces

you buy spore prints or syringe kits ……. and those mushroom medium kits from Amazon and grow them at home. Back when I grew mine there were no laws about psilocybin mushrooms, millions of them grew in the fields in Texas every spring. Spore kits were available in the mail cheap. Anyone can order spore prints or kits legally in all states except California, Idaho and Delaware ( or some state back east ), they are legal in 47 states. most web spore suppliers ship to California anyway…. and the city of Oakland has decriminalized psilocybin mushrooms and I’m told spores are available at the mushroom church in Oakland and on Oakland street corners down town in the refurbished brick street area. Just Google “ buy psilocybin spore prints “ or “ psilocybin Oakland California “ for spore sources and there are just zillions of growing videos on YouTube.

Note: growing pure slants of psilocybin mycelium can be tricky and takes a lot of care and practice. Sterile lab practices are a must. ( pun there if you get it ). Times have changed since my era and they are much easier these days. The videos spell it out clearly.

Something else I think I should mention is that getting high from psilocybin mushrooms is only an occasional thing. You cannot repeatedly get high from them in the short term. If you ate them ( 7 grams of bitter fresh dried carpafores ) today, it would be three to five clean weeks before you could have the same experience again. Eating more does not recreate the first experience . However …. That they have a valuable medicinal mental effect is well known and is what us croakers here on the group should be chasing if they want that valuable psilocybin benefit. In that case , eating a few grams ( 3-5 ) every day will induce that beneficial mental , Xanax like but way better , benefit. Being high from them in that case would be unnoticeable.

😁😁😁

cesanon profile image
cesanon in reply to Kaliber

""Everything you need is available on Amazon and spore prints are sold in Oakland, and Canada online. ""

I meant for dummies. Maybe some Amazon links?

And clearer directions for folks like me who haven't a clue about what "sport prints", "syringe kits" or slants are and how it all fits together?

Maybe a few recommended youtubes and some websites?

You assume way more implicit knowledge than I think most of us have.

If it's not too much effort would you please consider ABCing it for us.

Maybe with a warning that "This should only be done in jurisdictions where it is legal. Check your local laws before proceeding"

Kaliber profile image
Kaliber in reply to cesanon

Amazon , search Amazon for “ mushroomsupply.com all in one mushroom grow kit in a bag “ …3# and 5# sizes growing medium ….starting at $34. Also….. Google “ sporeworks.com Psilocybe cabensis , 4 pak of syringes “. $55. Search YouTube for “ how to grow magic mushrooms ( beginner friendly ) simple and fast “ for an easy video using the above.

Doesn’t get any easier than this. Naturally , if it’s illegal where you live , you will be breaking the law, proceed at your own risk. Magic mushrooms are close to going legal in many states , even federally … they are WAY at the very bottom of any law enforcement list. Just say’in.

spencoid2 profile image
spencoid2 in reply to cesanon

A sport print is a casual jacket with a printed as opposed to a woven pattern. A spore print is another matter altogether. The first three D printing even before there were nerds.

DMohr011 profile image
DMohr011 in reply to Kaliber

Last year whole going thru shit, I bought spores and all the Uncle Ben's fixings. Really needed a brain reset. So emotional when discussing my cancer and the reality of the future.

So the gathering began and supplies still sits in my closet for another day!

When I felt like shit, needed something to change that. Then RT and Keytruda kicked in and Mood changed.

Did plenty of shrooms back in the day. Would have to escape the wife today to enjoy them ( not the best of choices for a guide, for me ) . But my attitude changed with my healing. I guess I'll stick to my cannabis for now, and keep the UB for dinner!

Kaliber profile image
Kaliber in reply to DMohr011

I hear you brother … so much about this disease will definitely bring anyone down. I know what you are saying, anxiety , despair. Cannabis is a handy , reliable, treatment for emotional and physical depletion from this crap. You are probably doing the best thing for you … get some “ giggle weed “ and it’ll help a lot too yayahahahaya. Hang in there , do some QOL stuff to occupy your consciousness, take your mind off things.

❤️❤️❤️

Lulu700 profile image
Lulu700 in reply to DMohr011

Hahaha , 😂. “ escape, the guide “😂 oh boy , that is funny! 👏👏👏👏

Lulu700 profile image
Lulu700 in reply to Kaliber

You’re like Wikipedia …muey intelligence!

Kaliber profile image
Kaliber in reply to Lulu700

I dunno about intelligence, more like an Encyclopedia. Yayahahahaya

WSOPeddie profile image
WSOPeddie in reply to Kaliber

Kaliber -- you are our resident Renaissance Man and Shaman. Who knew? Seriously, you win the prize for most interesting comments. 😜

Lulu700 profile image
Lulu700 in reply to WSOPeddie

The most interesting man in the world . He does not often eat shrooms , but when he does it’s epic . He is a sage and a beaut of a humano. ❤️👏👏👏👏

Lulu700 profile image
Lulu700 in reply to Kaliber

We don’t call them “Majic” for nothing! 😎✌️

Kaliber profile image
Kaliber in reply to Lulu700

lol ❤️❤️❤️

podsart profile image
podsart in reply to Lulu700

how do u like the QOL AHCC immunokinko 750 AHCC; what did your nat onco say about it? I use it also; pricey.

spencoid2 profile image
spencoid2 in reply to podsart

so far this has the most support on this group. Anything more to say about it? Is it good for immune support during chemo? Sort of looks like turkey tail is best for that?

Lulu700 profile image
Lulu700 in reply to podsart

I ve blindly followed my Nat md onco .he really knows . This is the pricey one . He prescribes this for most people with C.. he said it promotes the natural killer cells . Good for us! I’m staying on it because I’m clear and dont want to change that?

podsart profile image
podsart in reply to Lulu700

thanks,good luck

Lulu700 profile image
Lulu700

agreed! I’m a fan !

Murph256 profile image
Murph256

My Chinese American gf recommended reishi. Apparently, it’s prescribed by traditional Chinese doctors as a supplement to help fight cancer. I take 600 mg a day in capsule form. Is it working? Who knows?

tayninhtom profile image
tayninhtom

I use the lions mane and turkey tail mushroom compound daily. Also the 50 mg niacin. Instead of taking a trip, my wife and I use the Microdosing, which I find is like Prevogen on steroids. It enhances a clarity in the brain that treatments take away. Regarding chemo, I found the best treatment for the low points during six months of chemo was marijuana. I never felt the buzz I got as a kid. It just removed the pain during those low periods. I’m curious whether the psilocybin will do the same. Please post if psilocybin is the route you choose.

Lulu700 profile image
Lulu700 in reply to tayninhtom

I’ve done it three times post dx and ayahuasca twice . All with great lasting spiritual relief . I lost fear of death from pc my first time with ayahuasca .. A week later, i got my first all clear from the MO . I’m not saying it cured the pc I had just finished imrt and was doing Lupron plus another adt . but prior to knowing I was clear I had already dropped the fear . No looking back . Im grateful to be alive and not to be in terrible pain. I’ve got all of the gripes and pains of a man with no T …. Sarcopenia, cognition loss, osteopenia, man tits , n9 balls , but no signs of pc . F pc ! It’s the The enemy of mankind ! No friend of ours! Free you mind and the rest shall follow . Take care . Live life! Pluck the day!

tayninhtom profile image
tayninhtom in reply to Lulu700

Amen brother. You just described life for many of us. And yet we will carry-on!

cesces profile image
cesces

"therapist recommended taking lion's mane with niacin before during and after the trip. "

I would be dubious.

You can never know the dosing.

And complex biological systems are unpredictable without clinical trials.

If it is powerful, you just don't know if it will help or hurt.

For instance, many people treat their prostate cancer with cannabis.

Prostate Cancer cells are well known to have extra cannabinoid receptors. Cannabis probably spurs the growth of prostate cancer... though without clinical trials you just don't know.

Logic doesn't work with complex biological systems.

PeteN profile image
PeteN in reply to cesces

”Cannabis probably spurs the growth of prostate cancer”? Where in the world did you come up with that? In fact, cannabis has been shown to be anti-androgenic and may cause increased apoptosis and cell inhibition in prostate cancer cells.

cesces profile image
cesces in reply to PeteN

Dr. Snuffy Myers clinical observations of those of his patients that were evangelizers of heavy self medication with Cannabis. His entire case load was composed of thousands of prostate cancer patients.

"anti-androgenic" irrelevant

"may cause increased apoptosis and cell inhibition in prostate cancer cells."

I am doubtful you have any high quality peer reviewed clinical trial evidence for that. But please... prove me wrong.

Given the increased number of cannabis receptors in prostate cancer cells, I think we can agree that cannabis is likely to have an effect on prostate cancer cells.

Until we get peer reviewed clinical trial evidence, I am inclined to go with Dr. Myers' clinical observations.

When and if I end up in hospice, I do intend to use cannabis for pain control. But not before then.

Thank you

spencoid2 profile image
spencoid2 in reply to cesces

cannabis effects people differently. no guaranty that it will help with pain at a dose you can live with. best to try it now to see how you do and if you will be able to function stoned. i just started chemo and decided to do RSO concurrently. I am stopping for a few days to do a mushroom trip. Will resume after. There is a very big difference in psycho-activity depending on how cannabis is ingested. Smoking or vaping is the fastest way to get high. Edibles are slower and will also get you high. Suppositories are also fast acting but have much less psycho-activity. I am currently taking step 3 which is about .2 gms of resin with 70 plus percent active canabanoids. Definitely feel a difference between oral and rectal oral administration.

PeteN profile image
PeteN in reply to spencoid2

ncbi.nlm.nih.gov/pmc/articl...

cesces profile image
cesces in reply to PeteN

"These tumors were treated with a range of cannabinoids, including WIN55,212-2, CBD-BDS (biological drug substance) plus Docetaxel, CBD-BDS plus bicalutamide, JWH015, JWH015 plus SA2 (specific antagonist), and Chromenopyrazoledione 4 (PM49, a synthetic cannabinoid). The duration of treatment varied from 14 to 38 days. Cannabinoids were administered orally, intraperitoneally, subcutaneously, or intravenously at doses between 0.5 and 100 mg/kg body weight.

3. Discussion

This systematic review highlights six studies reporting the effectiveness of both synthetic and phytocannabinoids in in vivo/xenograft models for prostate cancer. In this review, we have gathered detailed information on the study population, group size, cell lines that were used for inoculation and tumor generation, intervention that was used for treatment (natural/synthetic cannabinoid), dose size, route of administration, duration of the study, and reduction of the tumor size (Table 2). Two earlier systematic reviews [45,53,54] briefly explored the effect of cannabis in experimental models of prostate cancer, such as in vitro studies [42,47] and urological tumors [53,54]."

PeteN profile image
PeteN in reply to spencoid2

sperlingprostatecenter.com/...

cesces profile image
cesces in reply to PeteN

"Research since the March 2018 posting of the blog below supports the anti-tumor effect of non-psychoactive CBD (cannabidiol), one of 100+ identified plant-derived cannabinoid compounds. "

PeteN profile image
PeteN in reply to cesces

ncbi.nlm.nih.gov/pmc/articl...

cesces profile image
cesces in reply to PeteN

"Prostate cancer cells possess increased expression of both cannabinoid 1 and 2 receptors, and stimulation of these results in decrease in cell viability, increased apoptosis, and decreased androgen receptor expression and prostate-specific antigen excretion. It would be of interest to conduct clinical studies utilizing cannabinoids for patients with metastatic prostate cancer, taking advantage not only of its beneficial effects on prostate cancer but also of their analgesic properties for bone metastatic cancer pain."

PeteN profile image
PeteN in reply to cesces

aacrjournals.org/cancerres/...

cesces profile image
cesces in reply to PeteN

USELESS PETRI DISH CRAP

"Methods: In addressing the above questions, we employed the MTT assay to measure the antiproliferative effect on PC3 cells following treatment with varying concentrations of Cannabis sativa extract, cisplatin and cannabidiol. xCELLigence was also used to confirm the IC50 activity in which cells were grown in a 16 well plate coated..."

PeteN profile image
PeteN in reply to cesces

ncbi.nlm.nih.gov/pmc/articl...

spencoid2 profile image
spencoid2 in reply to PeteN

very interesting, i am checking all of these. the first one i understood many 2% but the conclusion was enlightening. hopefully by the time i have read them all i will have a better feeling about doing RSO concurrent with chemo.

spencoid2 profile image
spencoid2 in reply to PeteN

basically skimming the articles and studies because bio-chemistry is way beyond me. so far it looks like CBD is potentially the cannabanoid useful against prostate cancer.

I started the RSO regime which is temporarily on hold while doing a guided mushroom trip. Will start again three days after.

However I am wondering what the bet strains might be. I was using a concentrate that I made a lot of and had analyzed. It is close to 64% THC 9 active form but quite low on CBD, only about .4% CBD active form.

I also made an extract of which i might have enough form AC-DC plants of which I grew just two spindly plants and maybe got an ounce and a half of extract (BTW all my extracts are cold ethanol quick wash with sonication evaporation and subsequent decarboxilation. I have not had the AC-DC tested but can? Typically AC-DC is high on CBD and lower in THC but if you look at the samples tested by "reputable" labs the values are all over the map.

So does it make sense to use the AC-DC especially if I have it tested and it is high on CBD?

cesces profile image
cesces in reply to PeteN

MORE PETRI DISH

It all looks hopeful, but most drugs that look promising in petri dish never work in real life.

That we have not gotten any further than this in well over 50 years is not so promising.

"EXPERIMENTAL APPROACH

We tested pure cannabinoids and extracts from Cannabis strains enriched in particular cannabinoids (BDS), on AR-positive

(LNCaP and 22RV1) and -negative (DU-145 and PC-3) cells, by evaluating cell viability (MTT test), cell cycle arrest and

apoptosis induction, by FACS scans, caspase 3/7 assays, DNA fragmentation and TUNEL, and size of xenograft tumours

induced by LNCaP and DU-145 cells.

KEY RESULTS

Cannabidiol (CBD) significantly inhibited cell viability. Other compounds became effective in cells deprived of serum for 24 h.

Several BDS were more potent than the pure compounds in the presence of serum. CBD-BDS (i.p.) potentiated the effects of

bicalutamide and docetaxel against LNCaP and DU-145 xenograft tumours and, given alone, reduced LNCaP xenograft size.

CBD (1–10 mM) induced apoptosis and induced markers of intrinsic apoptotic pathways (PUMA and CHOP expression and

intracellular Ca2+

). In LNCaP cells, the pro-apoptotic effect of CBD was only partly due to TRPM8 antagonism and was

accompanied by down-regulation of AR, p53 activation and elevation of reactive oxygen species. LNCaP cells differentiated to

androgen-insensitive neuroendocrine-like cells were more sensitive to CBD-induced apoptosis.

CONCLUSIONS AND IMPLICATIONS

These data support the clinical testing...."

cigafred profile image
cigafred

One of our departed members recommended, and I am using, Turkey Tail from Oriveda. Expensive due to special extraction process.

spencoid2 profile image
spencoid2 in reply to cigafred

i used Turkey tail from Oriveda during radiation. i did a lot of reading online and it seemed at that time that very few providers extracted and tested in a way to insure consistency of active ingredients. At that time Paul Stamets was on the corporate money grab and was pushing all sorts of bullshit. So I settled on Oriveda. Now their web site has about 20% of the information it used to and they seems to be switching to fruiting bodies (not totally sure of this because there is so little information) instead of mycleium which they used to say was the only way to get high potency with an extraction process using both hot water and alcohol.

So at this point I am totally unclear as to what to buy. A friend has a big log with a huge Turkey Tail flush on it. I am going to get a few pounds and use it for teas as the Asians have for thousands of years. If someone can figure out what extraction method really makes sense and whether to use fruiting bodies or mycelium I would be appreciative.

SteveTheJ profile image
SteveTheJ

The shrooms are for psychiatric purposes correct? Maybe you should be asking this question elsewhere.

Kaliber profile image
Kaliber in reply to SteveTheJ

it’d be my own IMHO that psychiatric issues are one of the key aspects of guys like us facing our own unexpected eminent death. I’d go as far as to say that every single one of us , that are facing certain death, experience strong mental issues … i certainly do.

I’d hope that this group would allow for the whole experience related to terminal prostrate cancer …. Body AND mind brother. It’s not surprising to me that there would be strong interest in a beneficial mind salve for us guys deep in the throes of death. Psilocybin is widely thought to produce beneficial help in just exactly this kind of issue. Just say’in 😁😁😁

WSOPeddie profile image
WSOPeddie in reply to Kaliber

Not just the dire Grim Reaper issues. I've got plenty of unresolved issues from childhood that were resistant to psychotherapy. I'd like to be the best I can be when I approach the Pearly Gates. I've heard much about addiction and PTSD issues benefitting from these psychedelic mushrooms. Count me in.

Kaliber profile image
Kaliber in reply to WSOPeddie

yea, I hear ya brother . That reaper stuff cramps my style for some of my long term plans yayahahahaya yayahahahaya. If there are guys on here that tries and think they benefited from magic mushrooms, maybe they’ll report back for the group. That medical knowledge might be invaluable to both the guys and gals on here.

😁😁😁

spencoid2 profile image
spencoid2 in reply to Kaliber

i have my trip on Monday will report back

Lulu700 profile image
Lulu700 in reply to WSOPeddie

go for it!

spencoid2 profile image
spencoid2 in reply to SteveTheJ

no, health and immune support.

Vangogh1961 profile image
Vangogh1961

LMAO. I work with an elder population and many of them have age related aches and pains and many have availed themselves to the recreational gummies. Most with good success with pain or improving appetite after surgery.

Vangogh1961 profile image
Vangogh1961

These elders are not homeless, but certainly utilize the decriminalized drugs. I do admit they are somewhat unproductive in their 80's and 90's.

Kaliber profile image
Kaliber in reply to Vangogh1961

lol

WSOPeddie profile image
WSOPeddie in reply to Vangogh1961

That's me. A slacker. And I'm only 72! Starting my winter weed grow soon. Might have to expand that to shrooms.

Kaliber profile image
Kaliber in reply to WSOPeddie

kewl …. 😁😁😁

swwags profile image
swwags

Why are you so angry? How is anything you posted here in this thread of value to the OP? We're all dying of cancer. Would you deny an alcoholic one last drink on is death bed? People on this site are sick. No one needs this.

LessPaul profile image
LessPaul in reply to swwags

Reminds me of this old joke…

Prison guard is leading an inmate to his execution. Guard asks the prisoner, “Any last request?” Prisoner says, “I’d like a cigarette.”

Guard says, “You know those things’ll kill ya, right?”

Kaliber profile image
Kaliber in reply to LessPaul

lol

Kaliber profile image
Kaliber

I don’t know who Bethishere is … I guess this is activity above my pay grade. Yayahahahaya

Darryl profile image
DarrylPartner in reply to Kaliber

Bethishere is one of our community moderators

Kaliber profile image
Kaliber in reply to Darryl

ah … thanks big guy.

❤️❤️❤️

Lulu700 profile image
Lulu700 in reply to Kaliber

😂. Imagine that ! You’ve been moderated! 👏👏👏👏

Kaliber profile image
Kaliber in reply to Lulu700

not me … someone else .. it’s all good buddy.

❤️❤️😂

Lrv44221 profile image
Lrv44221

Yes, Medicinal Mushrooms are good if not great. They work to heal the immune

I take a mushroom complex that has a high potency combination of ABM, Maitake, Reishi

and Shitake. They are pricy because you take 4 each day but they helped me when i had cancer, and I hope they help mu husband with PC.

I use dr Beckers Mushroom complex.

I have the toll-free Phone if anyone is inte🌹🌹🦚🦚

Sun1115 profile image
Sun1115 in reply to Lrv44221

Yes Thank you for that toll free number for Beckers ?

Lrv44221 profile image
Lrv44221 in reply to Sun1115

go to bioinnovations.net to order

Sun1115 profile image
Sun1115 in reply to Lrv44221

Thank You for the reply. However , where do I start. Maybe a Mushroom complex but which one ? Too many choices.

spencoid2 profile image
spencoid2 in reply to Sun1115

We need someone with the abilities and tenacity of Tall Allen to figure out this mushroom thing. There is so much bullshit in the industry and companies change their tune as to what is best probably motivated by profit more than anything else.

I would love to find an authoritative review of active ingredients in medicinal mushrooms, their possible uses chemical mechanisms of action as well as analysis of commercial products for bioavailability of essential compounds. I have n ot found anything like this but am not the world's best googler.

DMohr011 profile image
DMohr011

I wish you the best on your magical journey! Totally behind you and anyone else that needs to reset the mind.

WSOPeddie profile image
WSOPeddie

I would add that Colorado is on the verge of legalizing the use and cultivation of psychedelic mushrooms. That proposition seems to be well ahead in the count such that I expect CO will join Oregon in this regard.

mtnwife profile image
mtnwife in reply to WSOPeddie

Colorado Proposition 122 passed this week with 51%of the vote making Colorado the 2nd state after Oregon to decriminalize mushrooms. (Denver actually decriminalized psylicibin mushrooms in 2019.)

spencoid2 profile image
spencoid2

next we need to put them in the drinking water. i believe that was proposed in the 70s or maybe it was acid. anyway couldn't hurt.

CAMPSOUPS profile image
CAMPSOUPS in reply to spencoid2

electric kool aid acid test. late 60's.

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