The joys of Lupron

[ShipModeler]

I am due to have my fourth, 3-month, Lupron injection. For two days following the shot my hip hurts like the dickens (whatever that is). Is this common?

[TylexGP]

I have the same thing happen every injection. I Am on my 6 th injection.

[Mjex in reply to TylexGP]

I recently had a three month lupron injection and it was given in a frontal area of my hip. When I asked why, the PA at Sloan Kettering said they were now moving the site because the rear of the hip (butt) site sometimes involved irritating the sciatic nerves. Makes sense to me and the shot area was not painful after a day or two.

[ShipModeler in reply to Mjex]

I swill bring this up with my OC. Thanks.

[esperandrich]

I just had my sixth shot of Lupron in September and I never had a problem with any of them. However, when the nurse gave me the shot I was standing up and put almost all of my weight on the opposite side of where the shot was given.

Maybe that might help next time.

[ShipModeler in reply to esperandrich]

I have been doing that technique. I think the discomfort comes from the Lupron because I don’t feel the injection. Thanks for your reply.

[Benkaymel]

I get a 3-monthly shot of Prostap (in UK) which I believe is very similar to Lupron. I have had 2 so far - in the thigh rather than hip and I stand up for it. I've had absolutely no problems with either shot. I get the impression that the nurse was very experienced and gave the injection very slowly and carefully so maybe that was the reason?

[ShipModeler in reply to Benkaymel]

thank you.

[Echotango51]

I have been on lupron every 3 months since 2016. It’s the nurse that gives me the shots, the ones that does it slow, no problem, the ones that does it fast, that’s when my hip hurts for a few days.

[Gl448]

Corrected: Lupron has multiple injection sites recommended by the manufacturer: upper arm, butt, thigh.

Ask your nurse to try an alternative site to see if you tolerate it better.

lupronprostatecancer.com/ab...

Lupron injection sites

[farmanerd in reply to Gl448]

Lupron is given via an intramuscular injection. From your link:

"LUPRON DEPOT offers multiple dosing options, so your doctor can choose the right dose for you based on your individual treatment needs. Each dosage is given as a single intramuscular injection, and has been studied in clinical trials and prescribed by doctors."

*******

Eligard is given by subcutaneous injection:

eligard.com/getting-started...

"ELIGARD is a prescription medication that must be administered by a physician. It is given as a single subcutaneous injection, which means it is injected with a short needle just under the skin."

*******

Firmagon is given by deep subcutaneous injection:

firmagon.com/firmagon-injec...

"FIRMAGON is given at a doctor’s office monthly as a deep subcutaneous (below the skin) injection into your abdomen."

[Gl448 in reply to farmanerd]

Good catch, but my point to the OP remains correct, it doesn’t always have to be in the butt.

I’ll edit the post.

[Foldem in reply to farmanerd]

I have pain at the injection site too, but I much prefer the Lupron in the butt over the Eligard shot in the belly.

[Hidden in reply to Gl448]

My Urologist insisted on giving it (eligard) in my belly......Very Uncomfortable. I'm now with an oncology team, they've been using my upper arm which, (depending on the tech) is very tolerable. Initial burn that lasts 20 minutes, then nothing. Except the lump...lol

[ShipModeler in reply to Hidden]

👍🏻

[dac500]

Why my Lupron shots are so uneventful?

[treedown]

I was on it for 2 years. I used alternating buttocks and rarely had discomfort beyond that nights sleep. I also rode my bike to and after most injections so that might have helped

[Muffin2019]

when I was on lupron it had the same effect so went to eligard when lupron was in short supply, the shot in the stomach area is not a big deal, it hurts for a few minutes, lump forms under the skin that goes away after a couple of months and alot less painful.

[London441]

Injecting slowly should solve it. Many nurses techs etc go too fast.

Count how long it takes and insist on slower if it does make the difference. Telling them as specifically as possible what you require (in seconds) gives them a unambiguous path.

[bean1008 in reply to London441]

Just had my Lupron shot the other day (two year anniversary) and the nurse injected it very slowly. I didn’t feel a thing with no issues afterwards!

[London441 in reply to bean1008]

Outstanding👍

[GummyToad]

30 seconds too long?

[London441 in reply to GummyToad]

It might be longer than necessary for you, but maybe not. I would experiment. I found 15-20 to be plenty.

[E2-Guy]

I refuse to subject myself to that nasty sh*t! 'Tap Pharmaceuticals/Abbott Labs' have made billions from their outrageously priced trimonthly Lupron injections that replaced the inexpensive 5 mg synthetic estrogen DES tablets in 1985. DES was banned due to the 'alleged' 30% increase in CV events by its usage. I'm sure that a number of those CV events would have occurred even without the DES since some of those men were predisposed to cardio issues anyway...kinda like many people supposedly died from COVID 19 when they died from something else like getting hit by a truck! My grandfather, father, and his two brothers all were on DES for years prior to 1985 and never experienced any CV issues or the nasty side effects brought about by Lupron jabs until DES was no longer unavailable.

Many of us are having great success with transdermal estradiol (tE2) such as the Patches and gels at a fraction of the cost of injections; both without the side effects (other than some degree of gynecostmastia). I spend about $25/month on the gel and haven't been to a doctor for over five years. The E2 'hormonally' castrates as opposed to 'chemical' castration by Lupron. If for some reason I was unable to obtain the gel that I have been using, I would opt to have my nuts chopped off (since they are just useless weight on the drag strip anyway) rather than to take those dreadful injections which obviously destroy one's QOL. I'm sure that Lulu isn't suffering from the all too common side effects of chemical castration?

I may be all 'wet' with this reply; however, I've scheduled the AUS implant early next year to help with that issue!

Wishing everyone the best,

Ron

[London441 in reply to E2-Guy]

Highly accurate numbers of Covid deaths aren’t possible since the majority of them are old people with one or more comorbities. So what? We Pca patients die from heart disease in exponentially greater numbers than cancer regardless of how we suppress T.

Yes it’s a cash cow for the pharmaceutical companies. So are scores of other drugs. Again not sure of your point.

Transdermal estradiol can be hard to obtain, it works for some and not for others, and it can be challenging to dose correctly. The side effects are probably more similar to Lupron than is reported, so despised is Lupron anecdotally. I had no issues with Lupron.

Also, if it matters to you, beware of estradiol-induced gynecomastia, extremely common with E2. It’s no joke.

[tayninhtom]

I get one every three months. If the nurses new, I make sure that she warms the shot up in her hand before giving it to me. Also like others have commented, make sure they go slow. The nurse also needs to stay away from the sciatic nerve.

[bobdc6]

After I started getting mine here,

webmd.com/a-to-z-guides/wha...

I couldn't even feel it.

[ShipModeler in reply to bobdc6]

Thanks

[Kenn2017]

I have been receiving Lupron injections in my abodomen ( 3 month) and have no after effects at all. Started in 2017 at Mayo and now at VA, same place and have no problem.

[EdBacon]

I've had Lupron and Eligard (same drug). I'd give Eligard a try. Eligard is much better IMO. It's injected into the belly fat and stings a little going in, but gone in 30 seconds. Lupron left me sore for several days.

They use the cold spray to numb up where the injection goes in and that helps too.

[moguzzi]

As has been mention elsewhere there are other shot location options. Over the years i've had them in my abdomen, my butt and my arm. I've found the arm is the least annoying and the irritating pain that comes with it recedes in a day or two. Maybe request that next time.

[bglendi53]

I always have trouble when the injection is on the left side. I do much better in the right butt for some reason.

[Hidden]

I never have your issue but my brains are mashed potatoes, I get hot flashes, poor balance, tired, feel like crap. Good Luck, we care.