Xtandi: My husband started Xtandi about... - Advanced Prostate...

Advanced Prostate Cancer

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Xtandi

MsHope profile image
10 Replies

My husband started Xtandi about 2 months ago after Lupron starting not working. PSA went down 150 points first month, then went up 19 points last time went down 12 points. Does this mean Xtandi is not working for him? We were expecting it to go down a lot. Anyone else have this experience?

Thanks in advance for answers.

Debbie

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MsHope profile image
MsHope
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10 Replies
Shooter1 profile image
Shooter1

Sounds like Lupron is working but not stopping aPca. Adding Xtandi is helping too. Some fluxtuation is not unusual.. Stay the course and we all wish you luck with treatments... You have lots of other options down the road if needed...

MsHope profile image
MsHope in reply to Shooter1

Thanks for reply.

MsHope profile image
MsHope in reply to Shooter1

I made a mistake in my original post. PSA Dropped 150 points 1st month, then went up 19 then went up 12 points. Is this a normal fluctuation.

Shooter1 profile image
Shooter1 in reply to MsHope

I wouldn't call that a normal fluctuation, But nothing to panic about... Give it a little longer and see if it stabilizes. With my PSA climbing 3 times one month and 4 times the next, I am concerned and hoping for a drop.. Next Fridays blood work will tell me if I should get a little more concerned and go back on Xtandi which was failing, but slowly.

MsHope profile image
MsHope in reply to Shooter1

Once again thanks for reply. Today, my husband has Dr. appointment. We are hoping for a drop or at least for PSA to stay the same. Wishing you a good outcome on your blood work.

Tall_Allen profile image
Tall_Allen

143 drop is nothing to sneeze at!

MsHope profile image
MsHope in reply to Tall_Allen

Thanks for reply

NecessarilySo profile image
NecessarilySo

I'm not a doctor so take this lightly. The way I see it, there is a sort of tug-of-war going on in your husband's body between the cancer tumors and the therapy. It could be that some of the tumors are resistant to the therapy, and therefore the PSA rises. My thinking is that the quantity of cancer cells is so great that the therapy is not able to overcome the growth. My advice is that he needs to reduce the volume of the cancer, by surgery or radiation or maybe chemo, or increase the amount of therapy. Or possibly he can reduce the cancer rate of growth with lycopene intake or heat applied to the tumors.

pubmed.ncbi.nlm.nih.gov/147...

cancerdefeated.com/using-he...

jbskiatook profile image
jbskiatook

I did not read that he continued with his Lupron. Did he continue with Lupron and add Xtandi? I have used Xtandi plus an Lupron alternate for 2 years with good results.

MsHope profile image
MsHope in reply to jbskiatook

Yes he is still getting Lupron injections every 6 months, Xgeva once a month and then Xtandi.

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