Splash Study (Lutetium+Enzalutamide t... - Advanced Prostate...

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Splash Study (Lutetium+Enzalutamide trial)

MikeMartin profile image
5 Replies

Hi All, has anyone been in the phase1 or phase 2 Splash Study? My MO is proposing to switch me to Splash Phase 3 arm ->Lutetium PSMA & switch current Zytiga hormonal therapy to Enzalutamide . I could not find much info about the results of the Ph1/2. Here is the link splashtrial.com/

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MikeMartin
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Shooter1 profile image
Shooter1

Just one more I am excluded from.... to0 much pretreatment

tango65 profile image
tango65

It seems a good trial. It is randomized to LU177 or enza or abi, but they allow crossover at progression and everybody may get the Lu 177 treament.

There is some recent data here

pointbiopharma.com/investor...

The PFS was 11.5 months.

CAMPSOUPS profile image
CAMPSOUPS

You've probably seen this link. France is included in the study sites for sure as you know.

clinicaltrials.gov/ct2/show...

MikeMartin profile image
MikeMartin

Thanks Guys having a look at the link now..

MateoBeach profile image
MateoBeach

Several Lu treatment centers have been using enzalutamide in hopes of increasing PSMA expression for Lu treatment in CRPC. One trial ongoing in Australia as I understand it.

Makes sense to try adding it after a first round of treatment and repeat PSMA PET scan to evaluate for subsequent treatments.

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