Erleada and Dizziness

[MJCA]

Hi Gents,

I don’t post often. I have been on Erleada, Lupron and Xgeva for over 4 years. I took a 3 month hiatus and saw my PSA go from 1.2 to 6.9.

I had my first PSMA PET scan. It showed mets to a number of areas on my skeleton. I started back up on my meds. About 2 weeks ago I started getting really dizzy. Vertigo was ruled out. I am having an MRI today of my brain. I doubt they find ANYTHING 😉.

Has anyone else on Erleada/apalutamide experienced any dizziness along with some nausea?

Thanks so much!

[tango65]

Apalutamide can cause nausea and is also associate with falls and seizures.

accessdata.fda.gov/drugsatf...

[tallguy2]

Yes, dizziness and falls.

[Hidden]

Hey MJCA! Hang n there Sir! Maybe drug combos contribute to this also? I did a test adt drug for seven years until recently . It made me nauseous and dizzy almost daily during this time . How did the mri go? I Hope good! 🙏

[EdBacon]

Apalutamide, like enzalutamide (Xtandi) crosses the blood brain barrier. Darolutamide (Nubeqa) does not. You might ask your doctor about switching over.

[MJCA in reply to EdBacon]

Thank you. A while back, I did try darolutamide for one month. It had me so depressed I wanted to eat a gun; I went back to apalutamide.

[Ian99 in reply to EdBacon]

Crossing the BBB sounds risky. Is there a good reason to do this if an alternative is available ?

[Hidden]

I've been on Lupron+Zytiga+Prednisone since November 2021. Had one dizzy spell in January, went to emergency room, many tests. Attributed to lack of hydration that morning. I had not been doing anything strenuous. But I did start drinking more water.Had another serious spell while playing golf in hot weather, almost passed out. But I just rested, hydrated, and rode the cart for rest of round.

[Bradley73]

Yes, not uncommon for some dizziness with Erleada along with stomach issues. I have been taking Erleada for 13 months and I have more stomach issues than dizziness. My PSA has been undetectable with 4 tablets daily,but I have cut back to 2 tablets due to my stomach. I do another test in October.

[MJCA in reply to Bradley73]

Thanks. Ironically I have been taking the med over 4 years.

[de-luke]

I've had dizziness and fainted once. My doctor was surprized at this. It is not a "know side effect". But I have heard several patients report dizziness. For me the issue lessened with time.

[MJCA in reply to de-luke]

Thanks. On the Janssen website it does list dizziness as an uncommon side effect.

[SteveTheJ]

No dizziness, no nausea. Perhaps some very mild nausea from time to time. My oncologist prescribed Provigil to help with fatigue and concentration; I think it helps with the nausea too.

[Gabby643]

I had vertigo with 4 tablets went to three and no Vertigo.