IV with 5-Fluorouracil in mCRPC patients

[dockam]

Just read this:

practiceupdate.com/c/138278...

I'm definitely in the heavily pretreated mCRPC: 21 Taxotere sessions, 13 Cabazitaxels so far. 7& 1/2 years of Lupron and PSA still creeping up.

Daily infusions with 5-Fluorouracil until progression. Yikes. They only had 29 in the study and Clinical benefit attributable to 5-FU infusion occurred in 8/29 patients. Hmmm

Fight on Y'all

Randy

[tango65]

Have you considered treatment with Lu 177 PSMA? There are several clinical trials

clinicaltrials.gov/ct2/resu...

What about biopsies and possible targeted therapies or immunological clinical trials, or protacs trials, or oral chemo trials?

[dockam in reply to tango65]

Hi, I'm still awaiting Kaiser medicare to approve the PSMA scan for me, and if there is a large enough area, a biopsy will be done to check the genetics.

[tango65 in reply to dockam]

Hope you get the approval soon. You may qualify for Lu 177 PSMA therapy if there is good expression of PSMA.

[dockam in reply to tango65]

Just got off the phone with Kern Radiology and they have emailed Kaiser 3 times, requesting an autho or the PSMA and still no response

[Dont08759]

I had weekly 5-FU Infusions with Leucovoran 33 years ago for stage C rectal cancer. One thing I learned, The FU does not stand for Fluorouracil! Do they still have you suck on hard candies so you don’t taste the drug?

[slpdvmmd]

I am always suspect of 5-FU use outside of colorectal cancer where it historically has some proven efficacy. My bias probably relates to my oncology service rotations as a medical student and as intern where 5-FU was often given just to "give something" since side effects were minimal in terminal patients with no viable and effective treatment option. Later pervasive 5-FU in office infusions by MO practitioners in the United States to late stage cancer of any type was a significant contributor to changes in reimbursement that essentially wiped out the in-office infusion business in the United States.