DNMT1-mediated epigenetic silencing of TRAF6 promotes prostate cancer tumorigenesis and metastasis by enhancing EZH2 stability

[FRTHBST]

Just published research on DNMT-1 epigenetic pathway in Prostate Cancer. Authors suggest "Our results also show that targeting DNMT1 with its inhibitor decitabine (an FDA-approved drug) is an appealing treatment strategy for CRPC patients through epigenetic suppression of both DNMT1-mediated DNA methylation and EZH2-modulated histone methylation."

Much prior research done on DNA Methyltransferases and their role in cancer.

This from 2016, pubmed.ncbi.nlm.nih.gov/263...

This, a 2018 computational pharmacology modeling of effective natural DNMT inhibitors. frontiersin.org/articles/10...

and this from 2016,

researchgate.net/publicatio...

The list includes, EGCG, Caffeic Acid, Lycopene, Curcumin, Genistein, Silibinin, Luteolin, Boswellic Acid, Quercitin, among others.

All this to point out that the above much discussed supplements have yet more evidence of a possible beneficial effect on Pca.

[Cooolone]

Just published?

Links are in reference to 2016 and 2018...

???

Am I missing something?

Lol

[FRTHBST in reply to Cooolone]

Sorry! Yes, the missing reference to the recent article is; nature.com/articles/s41388-...

[j-o-h-n]

EGCG, Caffeic Acid, Lycopene, Curcumin, Genistein, Silibinin, Luteolin, Boswellic Acid, Quercitin vs Chocolate chip ice cream (two scoops)....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 07/11/2022 12:48 PM DST