ADT Holiday

[alperk]

PSA dropped from 54.5 to 2.1 after first ADT treatment 8/21 then <.064, <0.64 <.064 for the next 3 month intervals of Lupron, Abiraterone, prednisone. I keep reading about ADT holidays. Under what conditions is that advisable?

[Tall_Allen]

If ADT is hard to take and you want a vacation. There is no other reason.

[Horse12888 in reply to Tall_Allen]

Given that IADT is not inferior to continuous, and that ADT does imperceptible damage to the CVS and bones, why should continuous ADT ever be recommended?

[Tall_Allen in reply to Horse12888]

Well, the data are inconclusive. In some men iADT is inferior.

nejm.org/doi/full/10.1056/N...

[Magnus1964]

Non. My advise is that if a treatment is working, stay with it. No vacations. Your only giving new lines of cancer cell a chance to find a work around to the drug.

[Kaliber in reply to Magnus1964]

Yes …. My thoughts as well. ❤️❤️❤️

[Lettuce231 in reply to Magnus1964]

I couldn't agree more, if it isn't broken, then don't fix it. I wouldn't take a vacation, it's opening the gates that have been firmly bolted.

[TylexGP]

There are many days my ADT and Zytiga kick my butt; but They are working and I have found staying active helps a lot.

[alperk]

ADT Vacation-I don't think so! Thanks for all your comments which straightened out my thinking. After 6 months I started losing strength and muscle mass which means ADT is doing it's job in suppressing testosterone. Why would I want to stop that? Be patient. I may have other stupid questions but meanwhile I am off to the gym.

[j-o-h-n]

If it works, dont' f--- it up....... direct quote from the U.S. population..........

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 06/13/2022 7:22 PM DST

[Mormon1]

Hang in there. Stop reading! Trust your cancer doc or get another. Good luck

Palmyra NJ 1920