Metformin, and Statins, Yet Again

[MateoBeach]

Just when you thought the door was slammed shut on any real benefit of Metformin for APC, it, and statins too, again show there is something of value going on there in this analysis of two trials. mTOR down regulation? Decreasing inflammation? Don’t know. Buy I am one non-diabetic who will keep these in my regimen. Very low risk, low cost.

Effect of Metformin and Statins on the Outcomes in Men With mCRPC

sciencedirect.com/science/a...

BACKGROUND

The associations of metformin and statins with overall survival (OS) and prostate specific antigen response rate (PSA-RR) in trials in metastatic castration-resistant prostate cancer remain unclear.

OBJECTIVE

To determine whether metformin or statins ± abiraterone acetate plus prednisone/prednisolone (AAP) influence OS and PSA-RR.

DESIGN, SETTING AND PARTICIPANT

COU-AA-301 and COU-AA-302 patients were stratified by metformin and statin use. Cox proportional hazards models were used to estimate hazards ratio (HR) stratified by concomitant medications, and a random effects model was used to pool HR. We compared PSA-RR using Chi χ2 test.

RESULTS

In COU-AA-301-AAP, metformin was associated with improved PSA-RR (41.1% versus 28.6%) but not prolonged OS. In COU-AA-301-placebo-P, there was no association between metformin and prolonged OS or PSA-RR. In COU-AA-302-AAP, metformin was associated with prolonged OS (adjHR 0.69, 95% CI 0.48-0.98) and improved PSA-RR (72.7% versus 60.0%). In COU-AA-302-P, metformin was associated with prolonged OS (adjHR 0.66, 95% CI 0.47-0.93). In pooled analysis, OS was prolonged among those treated with metformin (pooled HR 0.77, 95% CI 0.62-0.95).In COU-AA-301-AAP, statins were associated with an improved OS (adjHR 0.76, 95% CI 0.62-0.93), while there was no difference in COU-AA-301-P. There was no association with statins and OS in either COU-AA-302 groups. When pooling HR, OS was prolonged among those treated with statins (pooled HR 0.78, 95% CI 0.68-0.88).

CONCLUSION

Within the limitations of post-hoc sub-analyses, metformin and statins are associated with a prolonged OS and increased PSA-RR, particularly in combination with AAP

[Justfor_]

You wrote: "Very low risk, low cost."

The latter their main handicap. No space for kick-backs.

[Tall_Allen]

Nope. Just another useless retrospective analysis. Nothing to see here.

[Hidden]

At least, you’ve to Sydney! ❤️👏🏼👏🏼👏🏼🙏

[Seasid]

I actually believe in statins and even in metformin. I am using them 40 mg Crestor and 500 mg to 1.5 g of metformin. per day. I am considering to make a drug holiday. I talked to my doctor yesterday about it. She said that they don't help directly with the cancer but that they help with the changes in your body as a result of ADT. So yes, it is difficulty to decide what to do. If your cholesterol is low and you are not eating much, than probably you don't need them so much, otherwise it is safer to take them.

[Seasid in reply to Seasid]

I just received this new study about metformin: endocrinologynetwork.com/vi...

[twostrats]

Good information, I think. Too many acronyms for me to follow especially in the conclusion

[middlejoel]

Been using Metformin10 years or so upon my doc's recommendation. Even whe going on vacation.,

[irakor in reply to middlejoel]

Are you taking extended release metformin? What brand of metformin do you buy? I have read that some brands are causing problems and getting recalled. Have you experienced side effects such as diarrhea or nausea? I am considering adding metformin to my husband's treatment. Thank you!

[middlejoel in reply to irakor]

Hi,

The medication info that is attached to the pills states that the MFR is AUROBINDO PHARM. Can't find any info if its extended release. The MO wrote a prescription and I went along with it. As far as I know, I have not experienced any negative side effects. Where did you read about the recalls?

[irakor in reply to middlejoel]

Please see google.com/search?q=metform...

[j-o-h-n]

youtube.com/watch?v=FdrE5DK...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 06/10/2022 7:01 PM DST

[Seasid]

New information about metformin: endocrinologynetwork.com/vi...

[middlejoel in reply to Seasid]

Seasid, the info appears to apply to those that are diabetic. Are we to assume that it also works similarly for prostate cancer?

[Seasid in reply to middlejoel]

I read somewhere, only the title, that metformin doesn't work against diabetes if you are on ADT. What I am doing just right now is stopping every non essential medication like statins and metformin to see if I will feel better. I think after years on crestor I can afford that. (Crestor removed every excess cholesterol from my body.) That is good because a prostate cancer is hording cholesterol in order to use it as a fuel to produce testosterone ones it mutates to CRPC. At this point I may need to start Enzalutamide very soon, so I am trying to reduce the number of medication which is not absolutely necessary to fight cancer. I am stopping metformin, crestor, aspirin and the vitamins and minerals what I am taking. My PSA may go up. At the moment it is 0.65. I hope that they will prescribe me Enzalutamide at PSA 1. I don't want that a camuflaged (artificially reduced) PSA prevents me from getting the drug (enzalutamide) which is effective. It will be at least a drug holiday if not permanent. I think I deserved it. I was taking metformin in a hope that it can kill Cancer stem cells. I am not a doctor, but this is my desission and I will see how it will go. I am testing my morning blood glucose levels. I believe I may be prediabetic but even than I will try to keep the blood glucose in a normal range with exercise and lifestyle etc.

[Seasid in reply to Seasid]

I am also trying to get rid of my high blood pressure medication perindopril arginine with exercise and eating less salty food etc as it is negativity impacting bone marrow function. I will see how will all this go.

[Seasid in reply to Seasid]

I will stay with my high blood pressure medication perindopril arginine. I will use 5mg per day. I would like to keep my blood pressure under 140/90.