When to take Zytiga?

[ShipModeler]

I am just beginning Zytiga. I take meds for diabetes and A-Fib. Can anyone tell me how you incorporated Zytiga into your daily medication regime?

[6357axbz]

Sure, when I first started I’d wait till 2 hours after breakfast and made sure to let an hour pass before lunch. Pretty easy to keep that schedule. Now, however, I take in the early morning hours when I get up to pee. Say like 4:30AM. That pretty much insures it’s been at least two hours since I last ate and one hour before breakfast.

[ShipModeler in reply to 6357axbz]

Thank you

[KAgolf in reply to ShipModeler]

my hubby does the same--sometime in the middle of the night during bathroom break

[Gearhead in reply to 6357axbz]

I pretty much follow 6357axbz's routine for the reasons he stated. I generally have to get up and pee twice during the night. I take my 4 250 mg abiraterone capsules the second time I have to get up, which is usually somewhere between 4 and 6 AM.

[chickgreen]

I take mine first thing in the morning - before I do anything else. Then about an hour later (or a little more) I make myself some breakfast and have the prednisone.

[GoBucks]

Whenever I first wakeup I take the pills. Easy to wait 1 hour to eat. OK to have coffee right away if you need it.

[6357axbz in reply to GoBucks]

Black coffee. Cream is fat and will exaggerate the strength of the Zytiga

[GoBucks in reply to 6357axbz]

I use fat free milk.

[6357axbz in reply to GoBucks]

There you go 👍

[spencoid2 in reply to GoBucks]

That is what I have been doing but some times I get up late and don't want to wait for an hour for breakfast since I am running late. I was thinking of taking then late at night instead. Any reason to not do this? It is certainly more than 2 hours after dinner.

[Kittenlover50 in reply to spencoid2]

My husband was told by tge doc to take them at night when he got up. He only missed one time in 18 mo. Took the prednisone with breakfast. Some take zytiga when they go to bed.

[Kittenlover50 in reply to spencoid2]

Oh. If splitting dose of prednisone don’t take second one after bout 4 pm. Coukd cause trouble sleeping.

[spencoid2 in reply to Kittenlover50]

my MO reduced my prednisone to just once a day and it seems to work just fine. I forget the reason might have been the sleep issue.

[GoBucks in reply to spencoid2]

Sure you could do that. I work part time at home now so I am never running late. 🤓

[spencoid2 in reply to GoBucks]

Funny I work at home too but I am always running late and I am a tough boss.

[GoBucks in reply to spencoid2]

Ha. I don't start until noon or later. I go easy on me

[Hidden]

Full dose upon awakening. Then no food for at least an hour (I waited at least 2 to be safe).

During breakfast, I would take 1/2 of my prednisone (5 mg).

During lunch, I would take the rest of my prednisone (an additional 5 mg).

Prednisone might cause insomnia. And it might upset your stomach. I don't sleep well so I didn't want to mess with the insomnia potential. In a pinch, I have taken it on an empty stomach and no GI issues for me.

For a while it increased my BP and changing my prednisone dose didn't seem to help. It also gave me fatigue. So my MO cut my dose and I have been taking 1/4 dose with a small meal. My BP has gone back to normal and I'm going to see what happens if I titrate up. If it works I'll talk to my MO.

24. ¼ dose of Zytiga with a low-fat meal: Lower Dose of Prostate Cancer Drug with Food - National Cancer Institute

cancer.gov/news-events/canc...

25. ¼ dose of Zytiga with a low-fat meal: Low cost abiraterone - PMC

ncbi.nlm.nih.gov/pmc/articl...

26. Food Effect Study of Abiraterone Acetate for Treatment of Patients with Castration-Resistant Prostate Cancer - Study Results - ClinicalTrials.gov

clinicaltrials.gov/ct2/show...

[Kittenlover50]

My husband was told, by doc, to take when he got up at night. Only missed one time in 18 mo. Took prednisone with breakfast.

[Rogersw]

I’m the same usually wake up in night and take Zytiga then. Ps it only takes a week or so to get use to black coffee (and tea)

[Chrisbaird]

Have taken 50gm zytiga and 5pm prednisone 1 hour before eat in morning works well for me last 12 months with PSA below 0.01 . Previously was on 100 gm zytiga when started the drug but after 3 months had liver toxicity so needed to reduce dosage exercise diet seem to be my main routines to follow for best results

[leo2634]

I. Take it at early morning usually around 5am with a full glass of water . I then take my Prendisone at breakfast second dose with dinner.

[Hidden]

I take in the morning at least 1 hour before breakfast. I have a cup of coffee, with cream & sugar 1o-15 minutes after taking it. It's been working fine for three years. 1 prednisone after breakfast and one after dinner. However, we've been having dinner later with the warmer weather and daylight savings, and I think prednisone that late may be causing insomnia.

[DenDoc]

I am an early riser. I get up and read papers in the morning so I have my alarms on my phone set to take the Zytiga at the same time every day and before I wake my wife to get up and get our day going. I am the breakfast chef so it is more than an hour before we actually eat. I use my iPhone for pill reminders, especially the night pills that I must take with food. Works well for me especially if we are eating out since I carry a set of pills for both of us in my pocket.

[JazzMan42]

Been on arbi and pred for 3 plus years. Take pred in morning with breakfast then arbi at bedtime (I eat dinner early around 6 pm so two hour before arbi is easy.)

[woolspnr51]

My husband was offered this...$10,000./month, and opted to stay on Orgovyx.

[carbide]

I also am type II diabetes (metformin) and have afib (Eliquis).I take Zytiga at 6am.

[ShipModeler in reply to carbide]

Thanks.

[Bronzee]

I take 2x500 mg Zytiga when I stand up to pee at about 0530H. I take breakfast at0730H. 5 mg Prednisone after my meal and caltrate I am also on Pamorelin @6 months and Xgeva @3months .. inj

so far the PSA is steadily going down from 239 to .189 to .11.

I have no pain and waiting for my next PetScan with PSMA.

My last one showed mets in the Iliac region and a 1.7 cm mass on the prostate removal bed. I have no pain and side effects are hot flushes and loss of muscle mass. Needless to say I am pED.

Good luck and prayers for all of us warriors here.

[Poowater]

I take it at 6am then one hour later dexamethasone.