How to take Zytiga and Prednisone. - Advanced Prostate...

Advanced Prostate Cancer

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How to take Zytiga and Prednisone.

dpowellnt profile image
13 Replies

Hello. Just starting Zytiga and unfortunately, the Cancer clinic isn't open till Monday.

The Prednisone says to take on a full stomach. The Zytiga says empty stomach. Do you take them at the same time? Prescription says 2 prednisone daily at different times. Is that right?

Sorry for stupid question.

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dpowellnt
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13 Replies
GoBucks profile image
GoBucks

I take zytiga when I first wake up, even if 5 a.m. I don't eat anything for an hour. Then after bfast I take 5mg of prednisone. I only take 1 a day. When I used to take 2 the other was after dinner.

dpowellnt profile image
dpowellnt in reply toGoBucks

Thank you so much. I also found another thread on this that confirmed my suspicions. Thank you again.

Absolutely right...zytiga should be with empty stomach and prednisone should be with full stomach

dougnola profile image
dougnola

Hi dpowellnt, since I always pee at some point in the middle of the night, for max fasting, I’ve been putting Zytiga nightly in a nice easy to open pillbox on my nightstand next to a small glass of water. I can then ensure definite fasting about 4 hours before and after. I take prednisone with breakfast. Good luck! Dougnola

Gearhead profile image
Gearhead

I take Zytiga 2 x 500mg with plenty of water the second time I get up to pee in the night, which is usually about 4 am. I was told to take Prednisone with food, not necessarily on a full stomach. So I take 1 x 5mg with breakfast (together with some other meds), and 1 x 5mg with lunch or some mid-day food. I think this routine is similar to that of many others here.

Jirka profile image
Jirka in reply toGearhead

Hello. I would like to ask if you take zytiga twice a day after consultation of your doctor. In other words .... I havent read this regime before,that it is possible to use zytiga twice a day. Or maybe you use one pill at night and the other at 4....So Iam interested in your story. My daddy has severe problems with stomach after full dosage. We are going to try lower dosage 500 mg. But maybe the way how you take your zytiga could be helpful....

6357axbz profile image
6357axbz

Prednisone just after breakfast.

Zytiga two hours after breakfast and wait 1 hour before eating next meal

Magnus1964 profile image
Magnus1964

I was on a clinical trial with zytiga. I was told at first to take both zytiga and prednisone on an empty stomach. About one year into the trial my PSA started to rise. I was then told to take both with food. My PSA again started to fall. I was on the trial for 3 1/2 years before my PSA rose to the point that I was taken off the trial.

I not sure what to tell you. Maybe start with an empty stomach and to with food if your PSA starts to rise.

Faithhope11 profile image
Faithhope11 in reply toMagnus1964

What was your next treatment after zytiga failed?

Magnus1964 profile image
Magnus1964 in reply toFaithhope11

As I recall I went on the Provenge treatment for nodules on my lungs. It worked well. The nodules shrank and have stayed dormant since. That was 5 years ago.

My next ADT drug was xtandi.

Jeremiad53 profile image
Jeremiad53 in reply toMagnus1964

I take a 250 mg dose of Zytiga, once a day with a low fat low calorie meal. I have evolved to having unsweeted yogurt, with some blueberries, bananas, and a bit of Catalina crunch cereal.. it is great, gives it a crunch. I am 1 year of following this protocol, and my PSA is still essentially zero.. . .03 ... Ask your MO if you can do this.

FGSmith profile image
FGSmith

I take 2 500 mg of Zytiga around 6:00 am everyday, followed by breakfast around 7:15 am with my prednisone. I only take one 5mg of prednisone daily. Once you get on a schedule, it is not hard to keep doing it. Been on it 6 months now, and so far good results. Keeping the fingers crossed it continues.

Magnus1964 profile image
Magnus1964

For what it's worth I was on a drug trial with zytiga. When the trial began I was told to take zytiga on an empty stomach. After 2 years my PSA started to rise. I was then told to take zytiga with food and my PSA started to fall.

As to what's next, what treatments have you been on?

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