Fourth Jevtana/Carboplatin infusion delayed. PSA is Up 900 pts in three weeks.

[Mount_Rainier]

My fourth Jevtana/Carboplatin infusion was moved back a week due to extreme fatigue and poor blood work results. PSA elevated from 1168 to 2078 in the three-week time between scheduled treatments. About a week ago I lost stamina and became extremely weak and experienced shortness of breath. I was barely able to walk into the infusion center. The nurse drew the lads and said she would be surprised if the doctor would give the go-ahead for the chemo. Bone pain is back in full force.

Alkaline Phosphatase122 U/L - Aspartate Aminotransferase115 U/L - Alanine Aminotransferase40 U/L - Prostate Specific Antigen2,078.61 ng/mL

My oncologist wanted to give me an extra week between chemo to see if my stamina improved. He seems to imply that a fourth Jevtana/Carboplatin would be in order even with the PSA escalation. I offered up the possibility of switching to Doxitaxal/Carboplatin and he didn't think that would make that much of a difference. His immediate plan is to see if the stamina improves to allow chemo to continue. Any thoughts from members are welcome indeed.

CT and Bone Scans have been ordered. Waiting for appointment confirmation.

We're all in this together! Keep Going!

[Tall_Allen]

See what the scans say before continuing. Have you discussed Xofigo to help with bone pain?

[Mount_Rainier in reply to Tall_Allen]

Thank you TA ! My doctor has suggested Xofigo as an alternative to chemo if/when it's deemed necessary. I'll suggest he consider your comments, Also waiting for additional treatment until after the scans, I believe he is waiting for a specific amount of time to pass between scans for insurance authorization protocol. I will make sure that is the case. I asked him about a chemo break and he said he wouldn't advise it due to the high PSA numbers, Thanks again!

[Tall_Allen in reply to Mount_Rainier]

Xofigo seems to work synergistically with chemo. In this study, they were able to reduce the chemo dose when combined with Xofigo. I would also consider adding Provenge at the same time.

ejcancer.com/article/S0959-...

ncbi.nlm.nih.gov/pmc/articl...

[j-o-h-n]

Ah geez.......... Oh dear God give M_R a break (remember it's Easter this coming Sunday). I'll say a few words to the Big Guy for you. God Bless...

"We're all in this together! Keep Going!"

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 04/14/2022 6:34 PM DST