Xtandi & PSA

[Jackrow]

Began Xtandi in early March. PSA went up from 93 in late Feb. to 231 to latest 651 on 3/26.

At the same time a CT & bone scan did not show much metastases progression and I am largly pain free, although that can and has changed quickly at times.

Just coming off targeted radiation and just restarted chemo with taxotere.

Any thoughts or experience why PSA increasing dramatically? How many months did it take Xtandi users to see reduced PSAs? Are any Xtandi users also doing chemo?

Thx, jackrow

[Tall_Allen]

Tumors develop a genetic resistance to Xtandi (and Zytiga). Sometimes, Taxotere can reverse it, so that Xtandi may work afterwards. This would be a good time to start Provenge as well, if you haven't already.

[ontheroad589]

Sounds like what happened to me - I had a flare after starting, it leveled off in a month, then doubled twice in a row in 6 weeks so he stopped it, and started back on Chemo (doectaxel). The Xtandi had me so messed up that I had to have two tranfusions of red packed cells at Christmas just to get my hemoglobin back to 8 so I could re-start chemo. Got cyanotic and the whole bit- blue streaks on the tongue, swollen legs, swollen glands - it was rough. Xtandi seems to bite some folks right in the ass, especially if you failed Zytiga as well - which I did. Good luck - my PSA went from 220 in November to over 2500 by February, now back down to 1400 after three chemos...

[Jackrow in reply to ontheroad589]

Thank you. Quite concerning as I also failed Zytiga over a year ago. I hope the best for you.

[mlengle]

Hi,

As you likely have heard, these treatments affect everyone differently. After Lupron and Taxotare simultaneously I had about 6 months before PSA started rising.

Then 30 rounds exterior beam and HDR. That go me another 6 months. I went on Xtandi last January and onc took me off two months later. PSA had more than doubled and I picked up 6 more mets.

Xtandi appears to have not helped me at all. Good news was I had no SEs with Xtandi.

Personally I have not heard of taking chemo and Xtandi together. For some I think the combined SEs would be very difficult.

I hope something works for you, I’m now starting a PARP inhibitor.

Mike

[Jackrow in reply to mlengle]

Thank you- hope PARP works for you!