Yes. You are killing off (many) PCa cells. It is known that dying, and dead PCa cells give off PSA. Many guys have discussed this over the past couple of years.
I wish you a good outcome long term. Docetaxel is one of the proven (in Human Trials) approaches to extend life. Hang in there. From what has been discussed the symptoms are cumulative. Hope you have read about ice packs foor feet, hands, and scalp, along with fasting 1-2 days prior to each treatment for less side effects?
have been told sucking ice chips during treatment helps to relieve metallic taste and taste bud issues. To each their own on diet. “It all works, but nothing works well (curative)”. There was a Trial that proved cruciferous vegetables (broccili, cabbage, brussel sprouts, etc.) shrink tumor size. Mike
My husband has had 9 rounds of Docetaxel and 1 more to go. His PSA also went up a point here and there for the first 4 or 5 infusions. The Oncologist said that is normal. It has been coming down steady. Was at 35 when he started and it's 20.5 now. Lost all hair and head a Beautiful full head of hair. It will comeback. His side effects had been mostly severe headaches after each infusion for at least 24 hrs. He did have a couple of nauseous moments and some dizzy spells. Are you on predisone 5mg two times a day as well? Hang in there it will get back.
after 7 NO’s from Surgeons, and 2 No’s from Radiologists, had SABR at Mem Sloan Kettering in NYC in January (11 mos ago). PSA has come down significantly ever since. New low nadir this month (26 mos since Dx). Pylarify PSMA PET in Oct., showed no PCa in prostate or bones. Same 3 lymph nodes still pos since first CT scan in Oct 2020, although all 3 smaller in size. Will deal with those next. Process. Mike
No. As I keep saying, docetaxel only kills active cancer cells. There is no point to prophylactic treatment. I don't know how to say this more clearly.
I understand the idea that chemo works best when the cancer cells are multiplying, but then how does triplet therapy work? In my case, my first round of ADT (2015) pushed my PSA to undetectable in a month. If I had added abiraterone and docetaxel, it doesn't seem like the docetaxel would have had many reproducing cells to attack. So was I not a good candidate for triplet therapy had it been in use back then?
Yes, but if a de novo patient goes undetectable after a month of ADT isn't chemotherapy at that point superfluous just as you suggest the OP's chemo is?
PEACE1: "The first docetaxel cycle had to be administered within 14 days after randomisation and be at least 6 weeks after ADT initiation. Patients assigned to receive abiraterone received 1000 mg of abiraterone (four 250 mg tablets, orally) once daily plus prednisone 5mg orally twice daily, starting within 6 weeks after ADT initiation. "
ARASENS: "All subjects must receive ADT of Investigator’s choice (LHRH agonist/antagonists or orchiectomy) as standard therapy, started ≤12 weeks before randomization. For subjects receiving LHRH agonists, treatment in combination with a first generation anti-androgen for at least 4 weeks prior to randomization is recommended. Darolutamide or placebo was given within 6 weeks of randomization. Six cycles of docetaxel will be administered within 6 weeks of randomization."
My oncologist is shit! I've known it from start, I've asked and questioned all the same questions previously....
My cancer nurse and the oncologist were kinda fear mongering me into chemotherapy!
' what if you don't have it!!! You'll have never known!!!'
I look n feel like a plucked Chicken, now my toes are going numb and a strong possibility I've been put through chemo due to a doctor just being complacent!
Man, I hope you are right about that.. cause my PSA is rising 5th round is Jan 3rd I hope I see a downward trend.. funny my MO has not mentioned any of this.. S>MH
First I knowvery little about the UK healthcare system. I am curious. My question is, are you taking chemotherapy and ADT? Of stopped ADT when you started chemotherapy
I ask because when I went metastatic in 2004, my first line was immediately an injection of Lupron following by chemotherapy and a continuation of Lupron. PSA was 32.4 when I started. Two months later 3.0 when I started chemotherapy. PS ranged from 0.5 to 1.0 during chemotherapy with ADT.
Anyway, I wish you the best and kill the little bastards.
Hey Mate... Hope you have a Happy Christmas, a Blessed and Bright Chanukah and a Happy Kwanzaa.. in other words,, I hope the coming season treats you and yours well...
Peace on Earth and Good Will to all men.& all that Jazz... but most importantly...
"LOW" Numbers...for guys like US
Peace out from the Wizard of Wesley Chapel, Tampa Bay Fl... AKA Larry The Wizard Siegfried on FB, feel free to friend me.. and I will hook you and anyone else on here to a Private Mens only Secret group on FB ie: A Reluctant Brotherhood.. It's place where we can safely Laugh, Cry and share experiences between men that have PCa without offending anyone who does NOT know what WE face on a daily basis.
I know the feeling.. . After today's answer from my Team at Moffitt.. I know why people go Bonkers and walk in shooting.. (No I'm not remotely thinking about that).. but I sure get it..
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