Zytiga failing

[Roches]

Hi all

My husband has been on zytiga and Prednisone for advanced prostate cancer, now psa is rising and cancer is spreading.

My question is can dexamethasone be more effective in slowing progression when combined with zytiga?

Thank you

[Shooter1]

Short answer--------yes---------- extends usefulness of zytiga.

[Tall_Allen]

Switching can extend its useful life:

bjui-journals.onlinelibrary...

[PeteLG]

The switch is working for me so far for three months.

[Ramp7 in reply to PeteLG]

I just switched a few weeks ago. Next PSA will tell the tale. Seems it can be effective in 62% of cases. When effective, can last from 5 to 20 months. Just kicking the can down the road.

[Roches in reply to Ramp7]

Thank you for your reply, am going to speak to oncologist.

[Roches in reply to PeteLG]

Thank you for your reply.

[Two-oceans]

Was in the same situation. Zytiga and Prednisone not working. Tried Zytiga and Dexamethasone, unfortunately also didn't work. Really hopes it does for your husband.

[Roches in reply to Two-oceans]

Thanks for you reply hope you find something to help.