Exploring and comparing adverse effects between PARP inhibitors

[HopingForTheBest1]

For those of us on or considering PARP inhibitors, here is an excellent detailed paper from NIH -

ncbi.nlm.nih.gov/pmc/articl...

As with any treatment decision, we all hope that such will extend our lives and we will best deal with the side effects.

[mklc]

Thank you so much. Helps a lot. Best of health to you.

[HopingForTheBest1 in reply to mklc]

We are all here to help each other.

You had posted a year ago inquiring about a PYL PET CT scan. Did you get one? If so, where and how much did it cost?

[mklc in reply to HopingForTheBest1]

That's so thoughtful...thank you.

Yes I did in the UK. It cost about US $3,000.

Best of health to you.

[HopingForTheBest1 in reply to mklc]

Did it help?

[Hidden]

How have the side effects been for you personally? Did you have to do any dose adjustment?

[HopingForTheBest1 in reply to Hidden]

I have been experiencing several side effects, but they're tolerable. Fatigue, anemia, occasional nausea, cough, susceptible to blood clots (had a partial in left thigh; resolved with Eliquis). My dosage is 400 mg twice a day.

I am thankful that it controlled my PSA at undetectable level for over a year, longer than the 8 month average. PSA is back up to 0.14 in last 3 months. May be time for new treatment. Also considering PSMA scan; FDA expected to approve soon in the US, so I may not need to go overseas where it is currently available.

Will be discussing treatment options with Oncologist in next few weeks. Also getting 2nd opinion from UCSF Center for BRCA Research, Dr Pamela Munster (top notch).

Just had updated full body bone scan and CT of abdomen/pelvis/chest to help in the decision process.

Giving it everything I got! Hoping for the best.

[Balsam01]

Thanks for posting this!

[immunity1]

Thank you for the excellent article that looks at the QOL issues when PARP inhibitors are included in therapy. We tend to skip over some important adverse effects due to treatment in our forum.

[HopingForTheBest1 in reply to immunity1]

Totally agree. The bottom line though is that if a treatment has promise and can be effective, we need to pursue it and deal with the side effects as best we can. Unless, of course, the side effects become too severe and we have to cut and run.