Rising PSA

[3putt]

On Zytiga past 38 months. Great results. Now seeing a bump from .03 to .10 to today’s .25. Wondering how high they let it go before switching to next miracle drug?

[Hidden]

Your PSA may be rising, but it's still very low.

It's not recommended to change treatments based on PSA alone so I would start discussing when next to do imaging in order to see if there is progression. Then if/when there is progression, make a decision about the next treatment. That might still be quite a bit down the road for you.

[GoBucks]

Perhaps a switch from prednisone to dexamethasone is in order. That works for a decent percentage of guys.

[Hidden in reply to GoBucks]

I am a over a year out from my change to Dexamthesone so it worked for me. I realize that's only one data point.

[Tall_Allen]

PCWG3 guidelines for clinical trials is that 1.0 ng/mL is the minimal starting value if confirmed rise is only indication of progression.

[j-o-h-n]

Sink it already.....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 10/05/2021 10:07 PM DST

[EdBar]

At 0.5 and up PSMA scans are useful, at 2.0 and up Axumin scans become useful. Once your PSA hits a number where a scan is viable you can use a scan to see what is going on, perhaps it’s something you can address with radiation in order to buy time before moving on to the next treatment.You’re also at a point where Provenge is most effective while your PSA is very low. I’m in the same boat, after several years my undetectable PSA is now detectable, although still very low. I recently completed Provenge treatment and will review my status with Dr. Sartor next month. What I outlined above is the game plan he has laid out for me, thought I’d share, good luck. Let’s keep kicking that can down the road.

Ed

[Rodeoz15]

I have a stupid question. If one's prostate is still intact, can ADT still lower PSA to almost zero? Or will a prostate always generate some PSA.

[Hidden in reply to Rodeoz15]

I’ve been undetech six yrs with a prostate . Still on adt .

[Rodeoz15 in reply to Hidden]

Thanks!

[Teufelshunde]

Doesnt hurt to add sulforaphane (Broq brand in US) to your protocol. Read this clinical study. pubmed.ncbi.nlm.nih.gov/259...

[Shooter1]

Those tests--3 mo apart/?? If so still pretty good. My PSADT went to 12 days before Na-18 scans showed new mets==since zapped. Normal bone and ct scans were clear.