CT scan came back…“Adrenal Glands: There is a 2 cm mass noted in the left adrenal worrisome for metastasis. The right adrenal is enlarged to 1 cm.”
Has anybody experienced this and what course of action is necessary if any?
Xtandi and Xgeva are the current treatments.
This isn’t all that great news either…There appears to be involvement of nearly every vertebral body. As an example the entire vertebral body of L1 is sclerotic. There are partial sclerosis of the other vertebral bodies. There is a large sclerotic lesion noted in the midportion of the sacrum measuring approximately 3.6 cm. Sclerotic lesions are also scattered throughout the pelvis with near complete involvement of the right inferior pubic rami. There are also bilateral areas of femoral and sclerosis indicative of metastatic disease.
No evidence of pathological fractures.
Just celebrated 5 years since being diagnosed at 55 with BRCA2 !
Not going to do chemo because of thalassemia. Any other suggestions?
No pain, mostly Restless Leg Syndrome keeping up at night!
Written by
Rsdutcher7
To view profiles and participate in discussions please or .
yep....been asking for it for years! They won't prescribe it until chemo has failed and chemo hasn't been something we've been willing to risk because of risk with thalassemia.
Olaparib has been approved for prostate cancer last year. Since then, to my knowledge, you can get it if you are castration resistant, had Zytiga or Xtandi and have a BRCA2 (or different HRR) mutation. A chemo is not required before using it.
AstraZeneca writes:
"The full indication is for the treatment of adult patients with deleterious or suspected deleterious germline or somatic HRR gene-mutated mCRPC who have progressed following prior treatment with enzalutamide or abiraterone. Patients are to be selected for treatment based on an FDA-approved companion diagnostic test for Lynparza."
If you never got Provenge, you could discuss it with your dr. Provenge is the only approved vaccine for PC and it may offer a survival advantage.
Then you could consider treatment with Xofigo, Lu 177 PSMA or with Ac 225 or thorium. Xofigo treats only bone metastases, the others are systemic therapies treating the cancer anywhere in the body.
I keep seeing reference to the use of PARP inhibitors in a mHSPC setting and without having to wait for mCRPC or failure post chemo or Zytiga, etc.
Maybe it would be great to share those Oncologist's who exercise this option with their patients because not all do. Many stick like glue to the SOC and like my MO, prefer to follow the data and wait for disease progression in order to introduce the use of this avenue.
I would like to possibly explore this avenue and not wait until failure in order to try another line of treatment. I do say possibly... Of course I would consult with any said Oncologist and discuss my particular setting.
Appreciate the thoughts and apologies for off topic question.
We haven’t found anyone willing to not follow SOP which is driven by insurance as well. We tried off label years ago and told $20k/month. Now that it’s more widely covered though it’s be interesting to ask again. We asked last December and they said “no”.
You've probably have tried this.... For your restless leg syndrome massage your legs as much as you (or some other person) can. Get one of those battery operating vibrating units:
I have severe restless leg for most of my life and found that a combination of Mirapex and methadone really control it for me. I take 10-mg of Methadone and 1-mg of Mirapex daily.
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
update on husbands radiation to pelvic mets
New Hip Pain: Muscle or Met?💥 
Introduction - 56 years old, stage 4 - bone mets, lymph node and likely lung involvement
Advanced Metastatic P C with a PSA of 1.2?
updated scans post chemo
