Trial Involving Cabozantinib

[Hillwalker87]

Hi everyone,

Dad has been informed he may be potentially eligible for a trial involving cabozantinib and atezolizumab. Has anybody had any dealings with this and if so, did it seem effective?

Many thanks as always!

[Tall_Allen]

It had no effect as a monotherapy, but they are trying it as part of a combination. What are they combining it with?

[Hillwalker87 in reply to Tall_Allen]

I'm not too sure TA. We go to see the onc on Monday so I'll ask the question. He isn't strictly approved as yet, it's all dependent if his mets are extensive enough to qualify but seen as my dad rather stupidly has been dawdling for a couple of months even thought he is clearly resistant, she suspects he could be

[Hillwalker87 in reply to Tall_Allen]

He has a scan this evening

[Hillwalker87 in reply to Tall_Allen]

Hi TA, I've just called in the recording I made, it's atezolizumab

[Tall_Allen in reply to Hillwalker87]

immune checkpoint blockade. It looked good in early trials:

meetinglibrary.asco.org/rec...

[Hillwalker87 in reply to Tall_Allen]

In my dad shoes who is still working and really against the use of chemo, do you think this could be worth a go should he have this offered? The criteria set out by the onc was 'measurable disease' which she says he dosent have currently though suspects he may have after his next results

[Hillwalker87]

Hi Nal, I've been informed that it's atezolizumab

[Hillwalker87]

Thanks Nal! I've had a look online and from my basic interpretation, it looks as thought it has had some favourable response but I'm not the best with the technical jargon. Have you heard of such a trial and aware of the results thus far at all?

[ScottfromSD]

Hi. I spent one year on the cosmic 021 trial with Cabo and Atezo. It limited radiographic progression but it did not stop the psa from rising. It required Atezo infusions every 3 weeks. Cabo is a pretty brutal drug and required a dose reduction due to side effects.

[Hillwalker87 in reply to ScottfromSD]

Thanks for your input Scott, much appreciated 🙏

[noirhole]

My first trial was cabo. Was good for bone but not soft tissue. Ended trial when soft tissue showed progression. Agree with ScottfromSD side effects were tough and also had to reduce dose. Still suffering from neuropathy from the trial seven years ago. Hope it works for you as a combo therapy.

[Hillwalker87 in reply to noirhole]

Thanks mate, that's good to know. My old man is suffering degenerative neuropathy so it might not be for him

[tango65]

Discuss in detail side effects vs efficacy for your cancer with the people doing the trial. These drugs may have serious side effects:

accessdata.fda.gov/drugsatf...

accessdata.fda.gov/drugsatf...

[Hillwalker87 in reply to tango65]

Thank you very much 🙏

[tango65 in reply to Hillwalker87]

I wish you the best of luck.

[Hillwalker87]

Thanks Nal! 🙏

[JC531]

My father started the trial back in November 2020, and shrunk his liver and bone tumors. He got the liver tumors back in February 2020 and he passed away last week, but the Cabozantinib and Keytruda provided my mom and I some extra months with him.

[Hillwalker87 in reply to JC531]

Thanks for sharing your experiences and condolences on the passing of your father, a year in since dad was diagnosed and I hate this terrible disease 🙏

[JC531 in reply to Hillwalker87]

Hang in there and battle, we fought close to 7 years a Stage IV- Gleason 9 killer.

[Spyder54 in reply to JC531]

JC531,So very sorry for your loss. Kind of you to share your experience for others looking for something that works.

Our best to you and yours,

Mike

St Pete