More on natural inhibitors of P13K/AKT, also a reference to PTEN reactivation

[FRTHBST]

Just wanted to add a few more P13K/AKT inhibitors to the list in LearnAll's excellent post. As none of the epigenitic pathways are completely isolated, from the nuclear receptors outside the cells(of which AR is one), to the chromatin changes they induce when transported inside the cell's nucleus, to specific changes in protein structure that are associated with cancer metabolism, cancer suppressor genes like PTEN are also affected.

Indole carbinole 3 via inhibition of WWP1 upregulates PTEN, eurekaselect.com/190509/art..., article discusses reactivation of PTEN tumor suppression

Indole Carbinol 3, found in cruciferous vegetables, broccoli, cauliflower, etc.

This 2021 review article explores role of PK13K/AKT pathway and natural inhibitors in Neuro degenerative disease-still it is the same pathway that's implicated in so many cancers.

frontiersin.org/articles/10...

Baicalein, Chinese Skullcap

Apigenin, found in apple skin, berries and many other foods

Sichuan pepper, HuaJiaoin in Traditional Chinese Medicine

Dihydromyricetin

Ircariin

Rhodiola (Salidroside is one of several active derivatives)

Arctigenin, derivative of fructus arctii in TCM

Piceatannol, derivative of Resveratrol, this 2020 article examine ability of Piceatannol to bind to VEGF pathway,(another epigenitic pathway implicated in prostate and many other cancers).

pubmed.ncbi.nlm.nih.gov/328...

Amentoflavone, found in Ginko biloba and St John's wort

Puerarin, derivative of Peuraria lobata in TCM

Berberine

Astragalus

This list is not exhaustive, as demonstrated by LearnAll's post. As research goes on we'll learn the specifics of what these molecules do and how they work as agonists and antagonists to various epigentic changes implicated in Pca. For now, perhaps a two week on, two week off regimen of a variety of these supplements and herbs might be helpful. They all affect the P13K/AKT pathway and a revolving selection could hold at bay some of the evolutionary ability of cancer cells to eventually workaround whatever is thrown at them. Of course as Nal pointed out, there may be 17 different crossings requiring 17 different crossing guards, and we don't know the crucial ones.

Also, something to keep in mind is that these compounds, molecules and herbs are having effects on a range of epigenetic targets at once(St john's wort as HDAC inhibitor is one example).

[LearnAll]

Frthbst..Some great points you are making...one is ..its better to try to block as many pathways as we can...by various substances ..I mean a combination and assortment of dietary items and/or supplements.....and then, consider other ones like Statins, Metformin or Berberine and may be Doxycycline...Adventurous men can look into Mebendazole/Fenbendazole/Ivermectin or Niclosamide albeit with great caution and careful monitoring. .

I appreciate you adding more information to this important topic.

[Masirah]

There is increasing information on alternative treatments for PCa, that can surely not be ignored. Yet there are those who seek to ridicule this, calling it witchcraft. Maybe they are the allies of Big Pharma - who knows? The source of the information on alternative treatments is wide and varied. Much of it comes from people with verifiable curriculum vitas, who know what they're talking about.

[FRTHBST in reply to Masirah]

I agree. I don't think there is a necessary divide between alternative and non alternative approaches to cancer. One difficulty lies in our understanding or lack thereof of the disease process. It's hard to have a comprehensive rational discussion of something like cancer treatment when our knowledge of the causes and progression remain so fragmentary. The biology is complex. I recently read that of all the cancer drugs approved in Europe between 1985 and 2005 (approval being a process requiring placebo controlled random trials similar to our own FDA's), over half either had no effect or actually did more harm than good to patients.

In my own conversations with oncologists, treatment recommendations grounded in hard science were always based on statistical knowledge, because that's what we have. Treatment outcomes are probabilistic in the extreme. On more than one occasion, the recommended SOC was wrong within that framework because the Dr.'s in question either hadn't read all of the information related to my scans or perhaps the relevant scan was missing from the electronic records they had been provided with. In either case it was left to me to make an evaluation.

The traditional medicines of China and India for example, have centuries of observation behind them. Evaluating herbs that clearly are having a variety of effects, but may not be curative in all or any cases, is a daunting scientific task when we have problems evaluating the precise effect of a drug that's been specifically designed to work a certain way and doesn't.

That researchers continue to focus on herbs and molecules used in traditional medicine is probably not all due to some variety of confirmation bias. These are powerful substances, are well understood in terms of side effects and when used intelligently, can be extremely beneficial. Naturopaths seem to be a good resource for a practice combining tradition and western medicine. Check out Donnie Yance's book, "Adaptogens" as one example. I definitely choose to use all of the knowledge available in my own treatment decisions.

[Masirah]

I recommend that you read Chris Woollam's books on the Rainbow Diet. canceractive.com/category/r...

[FRTHBST in reply to Masirah]

Looks worth a read. Thanks!