prostate cancer that does not produce psa

[Concerneddaughter123]

Hi everyone.

My dad’s PSA has always been low, so when he was diagnosed, we were very shocked. His team checks his PSA, although PSMA have been more telling for him.

His PSA today is the highest it has ever been at 17. His last PSMA was better than the one before. Is it possible for prostate cancer to start making PSA even though it did not from the start?

[Tall_Allen]

Low PSA subtypes have to be watched with imaging, possibly an FDG PET too.

[fmenninger in reply to Tall_Allen]

Hi TA.

Could it be that his pca is not psma avid, thus not being detected on the psma pet scan?

[NanoMRI]

I cannot answer your question but based on my experiences and the volume of mets you share in Bio, I would be looking beyond PSA; as I do. There are multiple imaging contrast agents to consider, and I look beyond generalized rankings of which is 'best'. I also seek second options on imaging findings. Recently I had my second liquid blood biopsy - IMO worthy of consideration. Hope this helps. All the best!