Thanks to the support of the Fondation Louvain, the Belgian Cancer Foundation, and the Télévie telethon, the team quickly identified that these acidotic tumor cells responded in diametrically opposite ways depending on the fatty acid they were absorbing. Within a few weeks, the results were both impressive and surprising. “We soon found that certain fatty acids stimulated the tumor cells while others killed them,” the researchers explained. DHA literally poisons them.
The poison acts on tumor cells via a phenomenon called ferroptosis, a type of cell death linked to the peroxidation of certain fatty acids. The greater the amount of unsaturated fatty acids in the cell, the greater the risk of their oxidation. Normally, in the acidic compartment within tumors, cells store these fatty acids in lipid droplets, a kind of bundle in which fatty acids are protected from oxidation. But in the presence of a large amount of DHA, the tumor cell is overwhelmed and cannot store the DHA, which oxidizes and leads to cell death. By using a lipid metabolism inhibitor that prevents the formation of lipid droplets, researchers were able to observe that this phenomenon is further amplified, which confirms the identified mechanism and opens the door to combined treatment possibilities.
For their study, UCLouvain researchers used a 3D tumor cell culture system, called spheroids. In the presence of DHA, spheroids first grow and then implode. The team also administered a DHA-enriched diet to mice with tumors. The result: tumor development was significantly slowed compared to that in mice on a conventional diet.
This UCLouvain study shows the value of DHA in fighting cancer. “For an adult,” the UCLouvain researchers stated, “it’s recommended to consume at least 250 mg of DHA per day. But studies show that our diet provides on average only 50 to 100 mg per day. This is well below the minimum recommended intake.”
This is great stuff. For some reason I can’t recall right now, I have been under the impression that Omega 3 is not a beneficial supplement for us. Time to do some research on that.
My only concern is that an unnamed poster here always tells us that anything will cure cancer in mice, and he may know more than these Belgian researchers. Or not!
LOL- I guess I'm that "unnamed poster." If I had a pet mouse with Prostate Cancer, I would certainly bring it to those Belgian researchers to be cured. There is so much silly stuff like this that gets reported.
I should also repost the definitive omega-3 randomized clinical trial that proved without a doubt that omega-3 supplementation caused no difference in incidence any kind of cancer (including prostate, breast and colorectal cancers) compared to placebo, and its use resulted in no difference in deaths from any kind of cancer. That was among 25,871 human participants followed for a median of 5.3 years.
I take lupron xtandi and Zometa …. Several bp and bg meds and my team of docs told me to stay “ well clear “ of omega- 3 supplements. They were contraindicated. Before taking omega-3 supplements or any other thing supplementing your regular cancer meds, you should run it by your medical team first. There can be intricate negative involvements that you may never think of …or your medical team just plain may not want you to do it. I take over 20 supplements they have approved of.
I vaguely remember that is was something to do with the major cardiac disturbances that my adt causes … the omega-3s exasperate the problems. Normally omega-3 is good for the heart but not under these circumstances.
Plus various otc antihistamine drugs to manage the nightmare histamine kickback ( coughing and snot attack ) caused from frequent starting and stopping the opiate meds.
Includes the albuterol inhaler, epinephrine inhaler, Flonase inhailer, chlorpheniramine, Loratadine and senna to ease the opiate plugs. Imodium to manage the frequent metformin caused diarrhea.
Supplements:
Pectasol-c 9 of those daily
60 billion probiotics
Black seed oil …5X-TQ
Centrum
CoQ10 high absorption
Lycopene
Pomo-T , broccoli, turmeric, pomegranate, green tea
Boswellia extract
Circunmin, with black seed oil
BroccoMax
Optimized saffron capsules
Raw saffron flower parts, 18 or so of those threads chewed to supplement the saffron processed capsules.
Seems like half my meds are used to manage the S.E.s of half the other other meds. All my meds and supplements are closely reviewed by my medical team. The above conglomeration has successfully kept my psa level at <0.1 for the last 32 consecutive months. I’m one of the low percentage of men that experiences the “ adt zombie “ side effects and major alterations in bp, bg, heart rhythm, physical discomforts and mild to major intermittent physical pains.
We all have to find what works for ourselves… the choices seem unlimited and all of us are quite different. Extending our lives while feeling like we have a personal hand in things is what it’s all about for me….. so far, doing pretty well considering my starting psa was 1400-1600 , body systems totally failing and near shutdown, cancer literally everywhere in my body and my first offer of care was inpatient hospice. I’m still here, something is working.
As I can see from your list, you have chronic pain, asthma, High Blood pressure.I take the same medication except for the Flonase which is for me Anoro Elliptra.
Right now I am working on sevrage of the opiodes. I discontinued the Fentanyl Patches 87 mcg/hr and the hydromorphe.
I also had halfe my Methoprazine 25mg(12.5mg) and in 2 more weeks 6.75mg,
4 weeks later it will be finishe, I am also on Sertraline 200mg which will be halfe later.
That’s a big opiate load to wean off of, I know it’ll be difficult for you. Still , while it’s good to take a opiate vaca now and then, you’re probably gonna have to start back up before long. It just part of trying to manage your QOL, and that’s what is most important brother.
I like your comment about one half of your meds is used to counteract the SE’s of the other half, I can relate. And I think the percentage of ADT zombies is more than you think, you can add me to that club, I’ve been walking around with an ADT buzz in my head for years now, but it’s keeping my PSA undetectable or nearly undetectable so I’ll keep pulling the levers with various meds.
Well I hope the percentage is low but you are probably right. You mostly hear about the guys running marathons and bicycling 79 miles a day while on adt …. It seems like plenty of guys are in some version of my boat as well. I can’t walk 25’ without turning red face gasping for breath …my bp shooting up to 215/110. The leg muscles and back muscles very stiff and painful. Still , like you said ….my psa is still undetectable and I’ve got the meds to make me comfortable.
"The Physicians Committee is dedicated to saving and improving human and animal lives through plant-based diets and ethical and effective scientific research."
What misleading name.
I hate it when idealogues do that.
Whenever I see an intentionality misrepresentive name I know they can't be trusted.
It's usually only one side of most issues that does this.
The side most prone to believing in conspiracies.
If you look left and look right, and find yourself with a bunch of angry conspiracist obsessives.
What's important is whether the article is factual, not whether there is perceived bias. If there's something that's not factual about the article, please point it out. I didn't write it so it won't offend me.
Anyone trying to make a point can be considered to be biased.
Perhaps you will find this, published in the peer-reviewed journal, Nature Reviews Clinical Oncology , more trustworthy:
"Only 5% of agents that have anticancer activity in preclinical development are licensed after demonstrating sufficient efficacy in phase III testing,..Importantly, the growth rates of human-derived xenografts are considerably more rapid than primary tumors and, as a result, are much more likely to respond to antiproliferative agents."
This is why we should all ignore pre-clinical studies like the one you cited and most of the studies that many folks on this site like to post. Many patients would like to believe that such claims of efficacy based on mouse models will prevail in humans, whereas 95% will fail.
Quite so - but there are a multitude of issues here, and guys doing "supplements" like Kaliber on this site are basically throwing everything including the kitchen sink at the problem. When you do this there is no way to assess if these things work or not - but they probably give a whole mass of positive energy to what otherwise would be a hopeless situation. But you need to have enough info to get the dosage and the interaction right, because there are thousands of different molecules involved - with a finely balanced relationship in the body. So if things are improving while you are treating PCa as you choose - great. If they are not - do something different - preferrably based on solid science.
My way forward (at the moment) is through nutrition - preferring the natural foods that "may" help and avoiding those that "may" harm. So I have zero supplements, and only one drug (Zoladex) and hope the body will take care of the problem. Time will tell. We are all different, and none of has the magical cure. Its great with this site that we can learn from other members experiments and not just the one we have chosen for ourselves.
I, like you, trust my body to deal with foods. I know I don't know enough to overwhelm my normal digestive control systems by taking concentrated supplements. It strikes me that so many things could go wrong:
• it can have unintended consequences and help rather than hurt the cancer
• it can have unintended consequences on the immune system, the CV system, the nervous system, etc.
• it can have interactions with other drugs or supplements
• it can augment or hinder liver enzymes needed to detoxify or activate drugs
• it can affect the balance of the microbiome in unknown ways
•what's on the label may be different from what's in the bottle
• it can change the results of tests (e.g., PSA maskers or Ga-68-dechelaters)
I agree with you that there is a benefit in feeling that one is at least doing something actively about the cancer. The feeling of complete loss of control of one's own body is almost impossible to bear.
It makes sense to me as my blood data show a far closer relation of DHT with 3glycerides than with total T. It is known that Omega3 lowers 3glycerides. QED.
Funny, I remember reading the issue with the reports as to Omega-3 being detrimental to PCa patients was seriously flawed as it took data out of context. I don't remember the specific issue though. And I find it hard to believe because then all the high fish diet populace in the world would be ripe with PCa patients. Something akin to the "soy" problem with PCa as well. But there's a lot to be overlooked as well when you try to single out a substance from a cultural lifestyle and diet.
In any event, my GP switched me from using Fenofibrate to Vasepa to counter high lipids in my blood. Both the GP and my MO are aware and neither brought any concern to the table when I mentioned the supposed issue in regard to PCa and Omega-3...
Of course I'm now left to wonder if it is a mistake, lol. Or should I just eat a few pounds of Salmon per week and get it la natural...? Hahaha
I'll stick with seeds and nuts. Chia, Flax and walnut are good sources of omegas.
Chia Seeds vs Fish Oil: Omega-3 Content Both chia seeds and fish oil contain a lot of omega-3 fatty acids: a teaspoon of chia seeds contains about 720 milligrams of omega-3 fatty acids, compared with 800 milligrams of omega-3 in a teaspoon of cod liver oil and 470 milligrams in a teaspoon of herring oil [ 1, 2 ].
Chia Seeds vs Fish Oil: Omega-3 Content - HealWithFood.org
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Cancer tumor growth out of Mets on spine 
Selective Cancer Cell Killing and Tumor Suppression? (article)
Flaxseed oil, Omega-3's and lignans - good or bad with PCa?
Glutamine-blocking drug slows tumor growth and strengthens anti-tumor response
A biological “switch” which can cause cancer cells to self-destruct.
