Background/Aim: Methionine addiction is a general and fundamental hallmark of cancer due to the excess use of methionine for transmethylation reactions, termed the “Hoffman Effect”. Methionine addiction has been shown to be a highly-effective target for cancer therapy by methionine restriction with oral recombinant methioninase (o-rMETase) in preclinical studies, including patient- derived orthotopic xenograft (PDOX) mouse models of cancer. A clinical study of o-rMETase as a supplement showed a 70% reduction of PSA levels in a patient with bone-metastatic prostate cancer. Materials and Methods: In the present study, two advanced prostate-cancer patients took o-rMETase as a supplement for approximately one month. Results: One of the patients taking o-rMETase showed a 38% reduction of PSA levels and the second patient showed a 20% PSA reduction. Conclusion: o-rMETase shows promise for treating patients with advanced prostate cancer.
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Graham49
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That was interesting. I did a google search on ( oral recombinant methioninase ) and found numerous articles, all by the same research lab authors.
The results they're reporting look promising enough that I would hope that other labs would also look into this treatment that is claimed to be very safe as well as effective.
Methionine restriction and methionine restricted diets have been around for a while. Probably not enough money in it for big pharma for them to pay for a trial.
Methionine restriction induces apoptosis of prostate cancer cells via the c-Jun N-terminal kinase-mediated signaling pathway
Author links open overlay panelShanLuSara MHoestjeEugene MChooDaniel EEpner
Tumors are relatively more sensitive to methionine restriction than corresponding normal tissues, a phenomenon known as methionine auxotrophy. The current studies were undertaken to elucidate the molecular mechanisms for methionine auxotrophy of prostate cancer cells. We found that the activity of c-Jun N-terminal kinase 1 (JNK1) increased dramatically in response to methionine restriction. Over expression of wild type JNK1 by transient transfection enhanced apoptosis in response to methionine restriction, whereas over expression of a kinase inactive mutant of JNK1 protected PC-3 human prostate cancer cells from apoptosis. We conclude that JNK1 plays a critical role in signaling cancer cells to undergo apoptosis in response to methionine restriction.
Thanks Patrick, I thought you had probably written something about this. Using this enzyme, non vegans/vegetarians could benefit without changing their diet. I guess it might become available as a supplement, since it seems to be harmless, but hope clinical trials are done.
An interesting article. Could possibly be used more effectively in synergy with other supplements or meds. I would hope that future studies would consider that.
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