Methionine restriction using methionase shows promise for treating advanced prostate cancer

[Graham49]

Lowering and Stabilizing PSA Levels in Advanced-prostate Cancer Patients With Oral Methioninase

QINGHONG HAN and ROBERT M. HOFFMAN

Anticancer Research April 2021, 41 (4) 1921-1926; DOI: doi.org/10.21873/anticanres...

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Abstract

Background/Aim: Methionine addiction is a general and fundamental hallmark of cancer due to the excess use of methionine for transmethylation reactions, termed the “Hoffman Effect”. Methionine addiction has been shown to be a highly-effective target for cancer therapy by methionine restriction with oral recombinant methioninase (o-rMETase) in preclinical studies, including patient- derived orthotopic xenograft (PDOX) mouse models of cancer. A clinical study of o-rMETase as a supplement showed a 70% reduction of PSA levels in a patient with bone-metastatic prostate cancer. Materials and Methods: In the present study, two advanced prostate-cancer patients took o-rMETase as a supplement for approximately one month. Results: One of the patients taking o-rMETase showed a 38% reduction of PSA levels and the second patient showed a 20% PSA reduction. Conclusion: o-rMETase shows promise for treating patients with advanced prostate cancer.

[AlanMeyer]

That was interesting. I did a google search on ( oral recombinant methioninase ) and found numerous articles, all by the same research lab authors.

The results they're reporting look promising enough that I would hope that other labs would also look into this treatment that is claimed to be very safe as well as effective.

We'll see what happens.

[Graham49 in reply to AlanMeyer]

Sorry for the spelling mistake in title.

Methionine restriction and methionine restricted diets have been around for a while. Probably not enough money in it for big pharma for them to pay for a trial.

Methionine restriction induces apoptosis of prostate cancer cells via the c-Jun N-terminal kinase-mediated signaling pathway

Author links open overlay panelShanLuSara MHoestjeEugene MChooDaniel EEpner

doi.org/10.1016/S0304-3835(...

Abstract

Tumors are relatively more sensitive to methionine restriction than corresponding normal tissues, a phenomenon known as methionine auxotrophy. The current studies were undertaken to elucidate the molecular mechanisms for methionine auxotrophy of prostate cancer cells. We found that the activity of c-Jun N-terminal kinase 1 (JNK1) increased dramatically in response to methionine restriction. Over expression of wild type JNK1 by transient transfection enhanced apoptosis in response to methionine restriction, whereas over expression of a kinase inactive mutant of JNK1 protected PC-3 human prostate cancer cells from apoptosis. We conclude that JNK1 plays a critical role in signaling cancer cells to undergo apoptosis in response to methionine restriction.

[pjoshea13 in reply to Graham49]

old posts:

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-Patrick

[Graham49 in reply to pjoshea13]

Thanks Patrick, I thought you had probably written something about this. Using this enzyme, non vegans/vegetarians could benefit without changing their diet. I guess it might become available as a supplement, since it seems to be harmless, but hope clinical trials are done.

[Currumpaw]

Hey Graham49!

An interesting article. Could possibly be used more effectively in synergy with other supplements or meds. I would hope that future studies would consider that.

Thanks for posting.

Currumpaw