The April LEF mag has an editorial on Dopamine (the feel-good compound).
As we age, MAO-B (a monoamine oxidase) increases, causing a drop in dopamine.
Here are a couple of MAO-B inhibitors:
- Deprenyl (for those who don't believe in supplements) [2].
- Phellodendron amurense bark extract (for those who prefer to avoid drugs) [3] "It is a major source of huáng bò (Chinese: 黄柏 or 黄檗), one of the 50 fundamental herbs used in traditional Chinese medicine." [3].
It is also one of the two ingredients in Relora.
There are 10 PubMed hits for <prostate MAO-B>, including one from last May:
"The Antiproliferative Effects of Flavonoid MAO Inhibitors on Prostate Cancer Cells" [4]
Many brands carry Relora, e.g. [5]
The LEF alternative has B12, which I try to limit [6].
Phelezine seems very promising. Government recently did a phase II trial. Good results. I started 60 mg/day shortly after surgery in 2019. It's possible that it is mostly responsible for my beating the odds.
I found this and as I am not the exercising type of person, sounded appealing :
"Researchers from UT Health San Antonio are the first to show that a natural supplement made from the bark of cork trees is as effective as exercise in preventing the progression of aggressive prostate cancer."
Hi Patrick and thank you for posting this.This product may help managing weight too. Can we use Relora in addition to Mucuna L-Dopa? Or it will be too much?
Patrick, deprenyl is approved in the US for Parkinson’s, but is readily available overseas at low cost and without a script. I took it as a “smart drug” for over 10 years, but stopped when I was dx with PCa. Since you are suggesting that MAO inhibitors may have anti cancer properties, it sounds like I can resume deprenyl. Am I missing something here? Thanks.
"Pathologically, GAPDH {Glyceraldehyde-3-phosphate dehydrogenase} has been implicated in apoptosis, neurodegenerative disease, prostate cancer and viral pathogenesis ..."
"Most recently, it has been shown that GAPDH is a target for deprenyl related compounds ... and may contribute to the neuroprotection offered by those compounds."
MAO inhibitors are anti depressant meds which slow PCa growth. Its prescription med and requires careful avoidance of tyramine containing foods.A herb, St. John's Wort also has some MAO Inhibitor effect and is over the counter. St John's Wort does not require food precautions.
I used St. John's wort for years, then got fat and developed high blood pressure - St. J's wort spikes b/p like crazy! Replaced it with Holy Basil, which relaxes and dissolves low-level depression. St J's combats depression but in a stimulating way instead.
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My supplement list and mTor pathways role In metastatic prostate cancer. 
Prostate Cancer Diet Update - - 2
Things have taken a turn for the worse
And again news about clinical trials
