My supplement list and mTor pathways role In metastatic prostate cancer.

[No_stone_unturned]

More and more I’m seeing a connection between the mTor pathway and metastatic prostate cancer. I just got my advanced genetic testing results back and was told…”you guessed it,” an mTor mutation. My purpose of this post is two fold:

1) To share my list of supplements for those looking for a jumping off point for what I find to be the most promising.

2) To start a discussion on mTor inhibitors and evaluate real world success or failure rates.

[No_stone_unturned]

youthandearth.com/blogs/blo...

(also apologies, noticed I posted the same list twice it is now corrected)

Supplement list part 2

[No_stone_unturned in reply to No_stone_unturned]

ncbi.nlm.nih.gov/pmc/articl...

[KocoPr in reply to No_stone_unturned]

I’ve read the article but it is from 2009.

You may already know this but it might help some that don’t.

Here is a better way to get the latest articles that are cited by the older articles.

I put old article title in search engine with pubmed and then scroll to bottom of article to “cited by”

here is one of several recent articles on same subject.

pubmed.ncbi.nlm.nih.gov/350...

AbstractDeregulation of the PI3K-Akt-mTOR pathway plays a critical role in the development and progression of many cancers. In prostate cancer, evidence suggests that it is mainly driven by PTEN loss of function. For many years, the development of selective Akt inhibitors has been challenging. In recent phase II and III clinical trials, Ipatasertib and Capivasertib associated with androgen deprivation therapies showed promising outcomes in patients with metastatic castration-resistant prostate cancer and PTEN-loss. Ongoing trials are currently assessing several Akt inhibitors in prostate cancer with different combinations, at different stages of the disease.

[No_stone_unturned in reply to KocoPr]

Thank you for the feedback. I ran it by my MO and here was his response:

Conversation with oncologist

[tango65]

Ipatasertib may work in delaying the progression of mCRPC with PTEN loss

thelancet.com/journals/lanc...

[noahware]

I believe a time-restricted, low-cal/low-protein keto diet can help inhibit mTOR.

[KocoPr in reply to noahware]

from what I have just read on this is mTOR pathway has sevrral positive and negative feedback loops making it very difficult to use mono inhibitors.

Published: 10 March 2020mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges

cellandbioscience.biomedcen...

[No_stone_unturned]

sirolimus is an rx correct?