LHRH

[NOCanceros]

Hello Good people

I did PSA after 1month is increased from 0.29 to 0.39 directly i informed my Dr. in Germany he told me to check up PSA every month.

So he recommended if i reach PSA 1.0 =The development suggest that the medication alone is slowly missing part of it's efficiency. Check PSA in monthly steps. I would recommend the combination of Bicalutamid and LHRH when you reach PSA 1.0

Usually recommend Profact 3 Month Depot (9,45 mg Buserelin).if i reach my psa 1.0.

George

[Tall_Allen]

Do you have metastases? Why bother with an relatively ineffective drug like bicalutamide?

[lewicki in reply to Tall_Allen]

Would this drug be a good one for circulating prostate cancer cells ?

[Tall_Allen in reply to lewicki]

no - it's a weak antiandrogen. Why not use a stronger one.

[lewicki in reply to Tall_Allen]

After Lupron , Xtandi , Chemo, LU-177 , AC-225 and a PSA of >0.1 I am seeking something less destructive to my body while I am in maybe remission and kill any cellscirculating . Off ADT now for5 months and wow you really feel great getting T back in this body of a 21 year battle. Wishful thinking I know.

[lewicki in reply to lewicki]

As I understand it does not remove T. Works in different ways.

[GP24]

My PSA is rising and I will wait until it gets close to 10 ng/ml to start with ADT. If you ask Dr. Weise he will say: go ahead, until now I always thought you were afraid when the PSA value rises.

I asked his colleague, Prof. Heidenreich in Cologne, and he agreed with my plan.

On the other hand, I will probably zap my mets before I reach 10 ng/ml and reduce the PSA value this way.

[maley2711 in reply to GP24]

Th old reminder....treat the cancer, not the PSA???

[GP24 in reply to maley2711]

This is correct but on the other hand, a rising PSA value is usually an indication that the tumor is growing.

I refer to the study of intermittent ADT by Crook and Dr. Klotz:

nejm.org/doi/full/10.1056/n...

In this well-done study they restarted ADT when the PSA value got above 10 ng/ml. So it is not absolutely required to jump the gun below that level.

[bluesnjazz]

My own experience shows IADT to be effective for me while also limiting the life-diminishing side effects. Discovered a tumor in a lymph gland when my PSA reached 45. After 6 months of double whammy with both bicalutamide and leuprolide, the tumor was gone and PSA was essentially zero. So I took a year-long break from it all and started again when my PSA reached 5, using only bicalutamide only 1-2 months off and on (only very other or every third day), then after that stopped working (about 2 years later) started Lupron again, one-month shots 2-3 times a year. It's now 5+ years since starting this routine and my PSA is still under 1 and the scan last fall should no signs of a tumor.