Zytiga and prednisone, bowel problems

[Roches]

Hi, my husband has been on Zytiga and prednisone for about 3 months, he also has a kidney stent due to prostate pressing on lymph node which in turn was blocking urine flow.

His bowel habits have changed since then, ie loose stools and regularity changed.

Anyone else with these problems?

Thank you

[tango65]

Diarrhea and dyspepsia are side effects of zytiga.

"The most common adverse reactions (≥10%) are fatigue, arthralgia, hypertension, nausea, edema, hypokalemia, hot flush, diarrhea, vomiting, upper respiratory infection, cough, and headache. (6.1)"

accessdata.fda.gov/drugsatf...

[Roches in reply to tango65]

Thank you for your reply,it has confirmed what I thought.

Do you know if this improves with time?

[tango65 in reply to Roches]

He could reduce the dose and see what happens.

[Roches in reply to tango65]

Will speak to oncologist.

Thanks for help

[tango65 in reply to Roches]

Best of luck.

[Tall_Allen]

Ask your oncologist if you can reeduce the dose, and see if it goes away. Be sure he is taking on an empty stomach and doesn't eat for an hour afterwards..

[Roches in reply to Tall_Allen]

He is taking it on empty stomach.

Will see if he can lower dose

Thanks for your help

[j-o-h-n in reply to Roches]

Kidney/urinary stent is no reason for loose stools...

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 10/18/2020 10:07 PM DST

[Roches in reply to j-o-h-n]

Thank you