Prednisone withdrawals? Cold turkey.... - Advanced Prostate...

Advanced Prostate Cancer

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Prednisone withdrawals? Cold turkey...How bad can it be?

savingdaddy profile image
9 Replies

How would one feel if one forgot to take their daily steroid (10mg) for around 10 days? My Dad totally forgot to get a refill and did not load in his daily pill box. Just realized yesterday. Aye yai yai!

(And btw my Dad's left PCN is in place. He is feeling depressed.)

Thanks in advance!

Kimberly

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savingdaddy profile image
savingdaddy
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9 Replies

Is he taking it because he's doing chemotherapy or is there another reason?

When I did chemo, I found that I really needed it for the first 10 days, but didn't take it between day 10 and the next infusion because I had quite a bit of adema. My doctor said it was OK. It sure does help a lot with the side effects during the first week.

There shouldn't be any withdrawal problem at a dose of 10mg although some prefer to taper off to 5mg first.

savingdaddy profile image
savingdaddy in reply to

He started chemo last June 2019 and has been on Prednisone since.

in reply to savingdaddy

Is he taking Cabazitaxel now?

tango65 profile image
tango65

If he is taking prednisone along with zytiga , the situation is different from stopping cold turkey any glucocorticoid without taking zytiga. There will not be inhibition of the ACTH and he could develop hypertension, edema and hypokalemia with the possibility of arrhythmias.

If he is not taking zytiga and he has been taking prednisone daily for less than 3 weeks, most probable nothing will happen. If he has been taking prednisone for a long time, he could experience fatigue, nausea, vomiting, abdominal pain etc. etc.

mayoclinic.org/prednisone-w...

savingdaddy profile image
savingdaddy in reply to tango65

The latter..Thank you

tango65 profile image
tango65 in reply to savingdaddy

Best of luck!

Tall_Allen profile image
Tall_Allen

If he was taking it with Zytiga and he abruptly stopped prednisone, it could send his BP soaring and cause edema.

dadzone43 profile image
dadzone43

Often the adrenal gland are suppressed by high doses of corticosteroids and are delayed in restarting. That is why it is advisable not to go cold turkey. Mild case of Addison's disease.

j-o-h-n profile image
j-o-h-n

Your Daddy is now an official member of Health Unlocked.....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 09/23/2020 5:48 PM DST

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