Fast testosterone recovery after Zytiga mono-therapy.

[andrew61]

I stopped Lupron June 2019 and remained on Zytiga alone. One 500mg dose with breakfast.

Testosterone rose slowly, approximately 10-20 per month. My guess is 500mg Zytiga with breakfast and dinner might hold testosterone down but I didn't test this. My PSA continued undetectable.

In June 2020 with PSA 0.03 and testosterone 120 I stopped Zytiga because I was 12 months post SBRT - hoping for non recurrence.

Within 3 weeks my testosterone jumped to 710 and PSA to 1.2. So it appears that testosterone recovers very quickly after stopping Zytiga mono-therapy. This might be useful information for somebody wanting to try BAT.

I am back on Lupron with a reevaluation in 6 weeks. Hopefully I go back to undetectable although obviously uncured for now.

If possible I'd like to stabilize with Zytiga twice per day because the side effects of Zytiga alone were pretty manageable.

[Tall_Allen]

Why do you say "obviously uncured for now." You had whole pelvic RT, right?

[andrew61 in reply to Tall_Allen]

Forgot to mention that Pca reappeared on PET Choline scan once testosterone rose. Scan was previously clear.

[Hidden in reply to andrew61]

where did i t reappear?

[Dachshundlove]

Hi Andrew61

Great news about testosterone recovery miracle!

And, I’m with Tall_Allen— if you still have a prostate, you could be in a durable remission with a psa below 2.0. The prostate creates residual psa. Which is why Dr Kwon prefers to work with people who have had RP. It’s easier to interpret remission (via psa) if the prostate is gone.

Continued health to you!

[Hidden]

So you had less side effects with zytiga mono than now with lupron alone?

[Hidden]

Good info. I'm doing SPT (supra-physiologic testosterone). I've been doing it for just over a year and my PSA is 0.028.

I'm doing T cypionate 400mg/week and Zytiga 750-1000 mg/day. As a side note, I don't know what Zytiga adds to the SPT but I've asked both my oncs and they both told me that they don't know either but I'm doing great so I should just keep doing what I'm doing.

My serum T is 2000-3000. Great muscle gain, fat loss. Good libido.

If my PSA starts going up I might have to do BAT. Zytiga should help slam the T down immediately (plus my endogenous T production is probably zero by now).

In response to Miriammole, I have no discernable SEs from Zytiga but did from estrogen based ADT.